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Journal of Clinical Case Reports | ISSN: 2165-7920 | Volume 8
Clinical and Medical Case Reports
10th Orthopedics & Rheumatology Annual Meeting & Expo
10th International Conference on
&
August 31-September 01, 2018 | Toronto, Canada
Matthew B Carroll
Ocean Springs Hospital Singing River Health System, USA
Tocilizumab in the treatment of acute myocardial infarction: A review of what we know with a look to the
future
Statement of the Problem: Tocilizumab (TCZ) is an important biologic response modifier that Rheumatologists routinely
employ in the treatment of several systemic autoimmune diseases. TCZ binds to interleukin (IL)-6 receptors, inhibits cellular
activation, and mitigates inflammation by IL-6. In mid-2017 TCZ was approved by the U.S. Food and Drug Administration
for its first non-rheumatologic condition, the treatment of chimeric antigen receptor (CAR) T cell-induced severe or life-
threatening cytokine release syndrome in patients 2 years of age or older. With this approval and with the increasing use of
TCZ off-label for other nonrheumatologic conditions such as Castleman’s Disease and its variant TAFRO syndrome, where
else might TCZ be successfully utilized as treatment? Recently interesting data has been published regarding the possible use
of TCZ in the treatment of myocardial infarction. This review will focus on the role of IL-6 and it’s receptor in myocardial
inflammation and association with adverse clinical outcomes. Discussed are results from one animal study and two human
trials have been published that studied the effect of TCZ in patients with acute myocardial infarction. Finally, this review
summarizes the current data and makes recommendations for future clinical trial development in what hopefully will be a
promising application of TCZ for a serious non-rheumatologic condition.
Biography
Matthew B. Carroll is a board-certified Rheumatologist who is clinically active and currently employed by the Singing River Health System. He has had a passion for
clinical research and has been an active member of the growing research team at his community hospital. He retired from the United States Air Force in 2017 but
during his active duty service developed over 15 protocols and has published over 20 articles. A recent passion has been exploring the possible beneficial role of
an IL-6 blockade on acute myocardial infarction. He launched an ambitious protocol studying the short-term effects on major adverse cardiac events which though
it was eventually ended after futility analysis suggested no benefit, did enroll over 20 subjects and provided 180-day follow-up of data collection. He continues to
actively lobby the study of an IL-6 blockade in other areas of Cardiology.
Matthew B Carroll, J Clin Case Rep 2018, Volume 8
DOI: 10.4172/2165-7920-C1-016