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Journal of Clinical Case Reports | ISSN: 2165-7920 | Volume 8
Clinical and Medical Case Reports
10
th
Orthopedics & Rheumatology Annual Meeting & Expo
10
th
International Conference on
&
August 31-September 01, 2018 | Toronto, Canada
Anthony Galea
Galea Professional Medical Inc., Canada
Cytorich: A novel anti-inflammatory/catabolic and regenerative autologous blood-derived product for
osteoarthritis treatment
Statement of the Problem:
Osteoarthritis (OA) is degenerative joint disease characterized by cartilage damage and synovial
inflammation. Autologous blood-derived products target special inflammatory molecular pathways and have a beneficial
therapeutic effect for inflammatory pathologies. The purpose of this study was to assess the in vitro and in vivo anti-
inflammatory/catabolic and regenerative potential of a novel autologous blood product (Cytorich).
Materials and Methods:
Blood samples from healthy donors were incubated using different techniques for 24h and analyzed
for the presence of anti-inflammatory (IL-1ra), anti-catabolic (tissue inhibitors of metalloproteinases, TIMPs), regenerative,
pro-inflammatory (TNF-α, IL-1) and catabolic (matrix metalloproteinases, MMPs) molecules. Double-blinded controlled
clinical study was conducted to evaluate clinical effectiveness and safety of the final product using VAS and WOMAC scales.
Results:
The highest concentration of therapeutic molecules targeting inflammatory and degeneration pathways in OA, as
well as platelet-derived growth factor, was found in 24h 37
o
C incubated blood. However, the increased production of catabolic
MMP9 and TNF-α and IL-1 was detected in the product. We have found that this negative effect could be blocked by adding
citric acid making future OA treatment more safe and effective. Double-blinded controlled clinical study has shown a safety
and efficiency of this new product. The analysis of WOMAC and VAS scores revealed improvement in pain and daily activities
parameters.
Conclusion & Significance:
Cytorich is an efficient and safe autologous product for OA treatment since it has been reported a a
source of human bioactive molecules playing a key role in the fundamental processes stimulating tissue repair and regeneration.
Biography
Anthony Galea practices sport medicine in Toronto and is considered one of the pioneers in the uses and applications of platelet rich plasma in musculoskeletal
disorders. He has functioned as a sport physician for many professional and Olympic competitions and his clients includes some of the worlds best athletes. He is
also an author and researcher, his current research focuses on autologous cytokines for the treatment of osteoarthritis. He is married with seven children.
anthonygalea@mac.comAnthony Galea, J Clin Case Rep 2018, Volume 8
DOI: 10.4172/2165-7920-C1-016