Previous Page  3 / 9 Next Page
Information
Show Menu
Previous Page 3 / 9 Next Page
Page Background

Page 24

Notes:

Journal of Chromatography & Separation Techniques | Volume: 09

8

th

World Congress on Chromatography

September 13-14, 2018 | Prague, Czech Republic

Polymer Science and Technology

4

th

International Conference on

Joint Event on

&

Gilles Goetz

Pfizer, USA

A

pplications of a new chromatographic method using SFC technology

developed recently at Pfizer are described here. The EPSAmethod, as readout

of polarity, correlates retention on a specific stationary phase with the exposed

polarity of a molecule. Changes in retention can be interpreted by changes in

polarity induced by the presence of intra-molecular hydrogen bonding (IMHB):

indeed, IMHBs tend to impact molecular conformation, inducing hidden polarity

that results in a decrease in analyte retention on the EPSA

support.We

demonstrate

here the impact of this method on multiple beyond rule of five projects (NS5A,

Oxytocin Receptor, CXCR7 Modulator, others). Given that conformational

changes (induced and/or stabilized by the formation of IMHB) increases potential

for membrane permeability, we show here that EPSA, and the EPSA prediction

model, have significant impact in peptide drug design.

Gilles Goetz, J Chromatogr Sep Tech 2018, Volume: 09

DOI: 10.4172/2157-7064-C2-042

EPSA: a novel supercritical fluid chromatography technique enabling the design of permeable

cyclic peptides

Biography

Gilles Goetz is a Principal Scientist at Pfizer in Groton, Connecticut, USA. He received his BSc (1991) and PhD (1995) at the University of Strasbourg in France. After

his Post-doctoral studies at the University of Hawaii (1996-97) and of Neuchatel (CH) (1998-99) studying marine and fungal natural products, he joined Monsanto in

2000. There, he worked through mergers and acquisitions for Pharmacia and Pfizer successively in the natural product group, the HTS group (analytical support),

and the purification group. In 2010, he transferred to the expert purification group at Pfizer Groton and in 2011 to the molecular properties group. He is a part of

the team influencing medicinal chemistry design through insights into molecular properties such as polarity, lipophilicity, shape, and conformation that will impact

molecular behaviors like solubility, permeability, and efflux. They develop and use mainly chromatographic techniques (EPSA) to assess those properties, and work

towards predicting molecular behaviors.

gilles.h.goetz@pfizer.com