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Volume 7, Issue 5 (Suppl)

J Clin Trials, an open access journal

ISSN:2167-0870

Clinical Trials 2017

September 11-13, 2017

September 11-13, 2017 San Antonio, USA

4

th

International Conference on

Cl inical Tr ial s

Research on connective tissue rehabilitation: Ameta-analysis

F Buck Willis

Galveston Clinical Research Foundation, USA

A

bundant research has been conducted on connective tissue rehabilitation, focusing on contracture reduction. The purpose

of this study was to examine the different testing methods and experimental designs used to conclusively prove protocols

and modalities for contracture reduction. Sequential papers following the level of evidence (increases) have shown benefits in

case studies, cohort trials (for population confirmation) followed by randomized, controlled trials with cross-over arms and

or blinding. The highest level of evidence is the Meta Analysis or Systematic Review which is meaningful in proving efficacy

of a therapeutic protocol with one dependent variable. An example of this was the series of studies on dynamic splinting for

contracture reduction of joints including jaw, shoulder, elbow, wrist, knee, ankle, and toe. The connective tissue of these joints

have different lengths and alignment but the molecular structures are similar so protocols for contracture reduction (low

load, prolonged duration stretch) were hypothesized to yield the same results. This was proven in a systematic review by Furia

et.al .

(2013) which showed that a direct linear correlation existed between the hours of therapeutic stretching and reduced

contracture as measured with active range of motion. Other variables were examined separately including animal studies for

reducing surgically induced contracture, but the aggregate change in controlled trials was proven in the meta-analysis with

change in AROM as the dependent variable. Different studies are beneficial in testing unique variables, and a progressive

sequence of studies building the level of evidence to a meta-analysis is best to prove therapeutic protocols.

Biography

F Buck Willis after suffering an unsurvivable plane crash conquered the challenges of a brain injury and a 3-year series of operations to rebuild his legs by earning

four degrees and squatting 505lbs. He earned his Medical degree (MBBS) in the British Commonwealth with a PhD in Kinesiology before publishing 25 manuscripts

in eight years and being chosen as a Fellow of the American College of Sports Medicine.

BWillis@galvestoncro.com

F Buck Willis, J Clin Trials 2017, 7:5 (Suppl)

DOI: 10.4172/2167-0870-C1-019