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Dementia 2016
September 29-October 01, 2016
Volume 6 Issue 5(Suppl) J Alzheimers Dis Parkinsonism 2016
ISSN:2161-0460 JADP, an open access journal
conferenceseries .com
September 29-October 01, 2016 London, UK
5th International Conference on
Alzheimer’s Disease & Dementia
Michaela Defrancesco et al., J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)
Depression predicts imminent conversion from mild cognitive impairment to Alzheimer´s disease
Michaela Defrancesco, Georg Kemmler, W. Wolfgang Fleischhacker, Imrich Blasko and Eberhard A. Deisenhammer
Medical University of Innsbruck, Austria
Background: Mild cognitive impairment (MCI) has been suggested to represent a prodromal stage of dementia and confers a
high risk for conversion to Alzheimer´s disease (AD). In this study, we examined the predictive value of depressive symptoms
and neuropsychological variables on conversion of MCI to AD.
Methods:Our sample consisted of 260MCI patients seen at the PsychiatricMemory Clinic of Innsbruck between 2005 and 2015.
Neuropsychological and clincal data of the baseline and at least one follow-up visit were collected retrospectively. Depression
was assessed using the Geriatric Depression Scale (GDS). Univariate and logistic regression analyses were performed.
Results: Of the 260 patients (mean age 71.5±7.7 years) 83 (32%) converted to AD within a mean follow-up time of 3.2± 2.2
years. The univariate ananlysis showed higher age and GDS score and lower MMSE, verbal memory, Boston naming and Clox
I test scores at baseline in converting MCI compared to stable MCI patients. However, logistic regression analysis revealed
solely depression, MMSE and verbal memory scores as significant predictors of imminent conversion from MCI to AD.
Conclusion: Our results support the previously reported predictive value of deficits in verbal memory and lower MMSE scores
in the progression of AD. In addition, we found a strong negative influence of depression on MCI patients before imminent
conversion to AD. These results emphasise the importance of depressive symptoms in early stages of AD and their possible
impact on conversion from MCI to dementia stage.
Biography
Michaela Defrancesco has completed her university education in medicine and PhD in neuroscience in 2013 at the Innsbruck Medical University and finished her
psychiatric residency in 2015. She is the head of the memory clinic of the psychiatric department of the University Clinic of Innsbruck. Her scientific work focuses
on early signs and predictors of conversion from Mild cognitive impairment to Alzheimer´s disease.