dementia-2016_scientifictracks-abstracts

Notes:

Page 25

Dementia 2016

September 29-October 01, 2016

Volume 6 Issue 5(Suppl)

J Alzheimers Dis Parkinsonism 2016

ISSN:2161-0460 JADP, an open access journal

conferenceseries

.com

September 29-October 01, 2016 London, UK

International Conference on

Alzheimer’s Disease & Dementia

Ananya Bagchi et al., J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)

Pharmaceutical effect of

Murraya Koenigii

on Alzheimers disease - A review

Ananya Bagchi, Dillip Kumar Swain

and

Analava Mitra

IIT Kharagpur, India

lzheimer's disease (AD) is a disease which is being characterized by signs of major oxidative stress, the loss of cholinergic

cells, depletion of Acetylcholine enzyme and the excessive activity of acetylcholinesterase

this present review

we are trying to investigate the role of the total alkaloidal extract and its predomidant carbazole alkaloid Mahanimbine from

Murraya koenigii

(MKA) leaves on age related oxidative stress, free radical scavenging activity and its effect in cholinergic

pathway. The MKA helps to improve the level of protective antioxidants for free radicals scavenging activity such as glutathione

peroxidase (GPx), reduced glutathione (GSH), glutathione such as reductase (GRD), superoxide dismutase (SOD) and catalase

(CAT) in brain tissues. Interestingly a significant progress can be found with the addition of

Murraya koenigii

leaf extract,in

improving the acetylcholine (ACh) level and reducing the acetylcholinesterase (AChE) activity in Alzheimer’s diseased mouse

brain. On the other hand in several studies it was found that a carbazole alkaloid of

Murraya koenigii

which is known as

mahanimbine [3, 5-dimethyl-3-(4- methylpent-3-enyl)-11H-pyrano [5, 6-a] carbazole], can Inhibit AChE activity which was

being proved by Ellman's method .A review on AChE inhibitory activity of this carbazole alkaloid has not been reported

so far, and this review will help to study this activity of carbazole alkaloid mahanimbine, isolated from

Murraya koenigii

preventing Alzheimer’s disease.