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conferenceseries
.com
Volume 8, Issue 9 (Suppl)
J Clin Exp Cardiolog, an open access journal
ISSN: 2155-9880
Euro Cardiology 2017
October 16-18, 2017
October 16-18, 2017 | Budapest, Hungary
20
th
European
Cardiology
Conference
Rationale of chloride hypothesis for explanation of the activity of neurohormonal systems in heart
failure pathophysiology: Literature review
Hajime Kataoka
Nishida Hospital, Japan
U
ntil recently, most studies focused on the body fluid dynamics in heart failure (HF) pathophysiology through the control
of sodium, potassium, and water balance in the body, and through the regulation of solutes and water by the renin-
angiotensin-aldosterone system (RAAS) and antidiuretic hormone (ADH) to maintain arterial circulation. Chloride, despite
flanking sodium as its anionic counterpart in salt, has remained largely ignored, presenting in the medical literature and
in clinical practice as an afterthought to the more popular electrolytes sodium and potassium, or simply as a substitute for
bicarbonate to preserve electro-neutrality. I recently demonstrated that changes in vascular volume are independently associated
with the serum chloride concentration during worsening HF and its recovery. Based on these observations and the established
central role of chloride in the RAAS, I have proposed a unifying hypothesis of the chloride theory for HF pathophysiology,
which states that changes in the serum chloride concentration are the primary determinant of changes in plasma volume and
neurohormonal activity under worsening HF and its resolution. Though speculative interaction between changes in serum
chloride concentration and neurohormonal systems has been given to the proposed hypothesis, it is unknown whether their
interactions would correctly work under this hypothesis. Thus, the present study aimed to determine a scientific rationale
of chloride hypothesis for explanation of the activity of neurohormonal systems, mainly the RAAS and ADH axis, in HF
pathophysiology through the current literature review.
Biography
Hajime Kataoka works as a Cardiologist and as a Physician-Scientist at Nishida Hospital, Oita, Japan. He obtained his MD degree from Kagoshima University in
1977 after which he completed specialty training in Cardiology. He has developed diagnostic methods for body fluid retention by using thoracic ultrasonography
searching for pleural effusion and by using body weight/fat analyzer for monitoring of body fluid status. Recently, he is investigating the body fluid status and
cardio-renal interaction in heart failure pathophysiology. He served as an Editorial Board Member of World Journal of Cardiology and Case Reports in Cardiology.
hkata@cream.plala.or.jpHajime Kataoka, J Clin Exp Cardiolog 2017, 8:9(Suppl)
DOI: 10.4172/2155-9880-C1-078