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Volume 8

Journal of Alzheimers Disease & Parkinsonism

ISSN: 2161-0460

Euro Dementia 2018

May 24-25, 2018

May 24-25, 2018 | Vienna, Austria

11

th

International Conference on

Alzheimers Disease & Dementia

MRI in dementia: Characteristics and relationship of atrophy and cognitive function

Nedim Ongun

Burdur State Hospital, Turkey

Introduction:

The prevalence of dementia is rapidly increasing in developed countries because of significant increase in

aging population. In order to be able to make a faster and more accurate decision, the importance of imaging in diagnosis

and treatment is increasing steadily. Magnetic resonance imaging (MRI) is one method by which the extent, impact and

possible etiology of regional brain pathology can be quantitatively assessed. The aim of this study is to reveal the imaging

properties of dementia and investigate the relationship between MRI and cognitive score within the vascular dementia (VaD)

and Alzheimer’s disease (AD).

Methods:

1024 patients diagnosed with dementia were evaluated retrospectively and grouped according to clinical features.

Demographic characteristics and risk factors were recorded. MRI scans were scored using Scheltens' scale and visual analogue

scale. The Mini-Mental State Examination (MMSE) was used to assess the cognitive status. Patients were compared based on

MRI measurements and MMSE scores.

Results:

242 patients without an MRI were excluded. 398 patients were probably suffering from AD with NINCDS-ADRDA

criteria; 249 patients were probably suffering fromVaDwith NINDS-AIREN criteria and 135 patients were with other dementia

subgroups. In MRI ratings, global atrophy (GA) and white matter hyperintensity (WMH) scores were significantly higher in

VaD group (p<0.001) and medial temporal atrophy (MTA) scores were significantly higher in AD group (p<0.001). Age, WMH

and MTA were significantly related to GA in VaD and AD groups. While WMH and MTA were associated with both groups,

age was also associated with MTA in AD group. MMSE scores were associated with MTA in both VaD and AD. There was a

significant association between MMSE and WMH in the VaD group but not in the AD group.

Conclusion:

This study is important for the evaluation of dementia related imaging properties. We conclude that clinical

dementia is accompanied by brain tissue loss, regardless of etiology. These results may affect future investigations aimed at

primary or secondary prevention of VaD and AD. Although selected treatments may vary, clinical outcomes are likely to be

tied to slowing or preventing brain tissue loss.

Biograpy

Nedim Ongun has completed his Neurology Residency and is working as a Neurologist. He is also pursuing his PhD in Physiology at the university. He has published more

than 25 papers in reputed journals and has been serving as a Referee and Editorial Board Member.

nedimongun@yahoo.com

Nedim Ongun, J Alzheimers Dis Parkinsonism 2018, Volume 8

DOI:10.4172/2161-0460-C3-042