

Page 44
Notes:
conferenceseries
.com
Volume 8
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Euro Dementia 2018
May 24-25, 2018
May 24-25, 2018 | Vienna, Austria
11
th
International Conference on
Alzheimers Disease & Dementia
MRI in dementia: Characteristics and relationship of atrophy and cognitive function
Nedim Ongun
Burdur State Hospital, Turkey
Introduction:
The prevalence of dementia is rapidly increasing in developed countries because of significant increase in
aging population. In order to be able to make a faster and more accurate decision, the importance of imaging in diagnosis
and treatment is increasing steadily. Magnetic resonance imaging (MRI) is one method by which the extent, impact and
possible etiology of regional brain pathology can be quantitatively assessed. The aim of this study is to reveal the imaging
properties of dementia and investigate the relationship between MRI and cognitive score within the vascular dementia (VaD)
and Alzheimer’s disease (AD).
Methods:
1024 patients diagnosed with dementia were evaluated retrospectively and grouped according to clinical features.
Demographic characteristics and risk factors were recorded. MRI scans were scored using Scheltens' scale and visual analogue
scale. The Mini-Mental State Examination (MMSE) was used to assess the cognitive status. Patients were compared based on
MRI measurements and MMSE scores.
Results:
242 patients without an MRI were excluded. 398 patients were probably suffering from AD with NINCDS-ADRDA
criteria; 249 patients were probably suffering fromVaDwith NINDS-AIREN criteria and 135 patients were with other dementia
subgroups. In MRI ratings, global atrophy (GA) and white matter hyperintensity (WMH) scores were significantly higher in
VaD group (p<0.001) and medial temporal atrophy (MTA) scores were significantly higher in AD group (p<0.001). Age, WMH
and MTA were significantly related to GA in VaD and AD groups. While WMH and MTA were associated with both groups,
age was also associated with MTA in AD group. MMSE scores were associated with MTA in both VaD and AD. There was a
significant association between MMSE and WMH in the VaD group but not in the AD group.
Conclusion:
This study is important for the evaluation of dementia related imaging properties. We conclude that clinical
dementia is accompanied by brain tissue loss, regardless of etiology. These results may affect future investigations aimed at
primary or secondary prevention of VaD and AD. Although selected treatments may vary, clinical outcomes are likely to be
tied to slowing or preventing brain tissue loss.
Biograpy
Nedim Ongun has completed his Neurology Residency and is working as a Neurologist. He is also pursuing his PhD in Physiology at the university. He has published more
than 25 papers in reputed journals and has been serving as a Referee and Editorial Board Member.
nedimongun@yahoo.comNedim Ongun, J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI:10.4172/2161-0460-C3-042