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Pharmaceutica Analytica Acta | Volume: 09
September 20-22, 2018 Prague, Czech Republic
Pharmaceutics & Drug Delivery Systems
17
th
Annual Congress on
Targeted pharmacological regulation of intracellular signal transduction in regenerative-competent cells:
A new direction of therapy in regenerative medicine
Gleb Nikolaevich Zyuz`kov
Tomsk National Research Medical Center, Russia
A
dvances in the field of cellular technologies have led to the possibility of developing a new direction of targeted therapy in
regenerative medicine - Strategy of pharmacological regulation of intracellular signal transduction in regenerator-competent
cells. The role of NF-кB, IKK, PKC, PKB, PI3K, ERK½, p38, adenylate cyclase, PKA, JAKs, STAT3, JNK and p53 in the realization of
functioning progenitor elements of different classes and cells of tissue microenvironment was studied in vitro by means of cultural,
immunological and the other methods. On the models of post hypoxic encephalopathy, skin wound and cytostatic myelosuppression
in experimental animals the therapeutic effects and mechanisms of action of modifiers of signal molecules activity were studied. The
specificity of the involvement of several signaling molecules in the regulation of cell cycle and development of progenitor cells of
various classes, as well as in the production of humoral factors by microenvironment cells was revealed. The neuroregenerative effects
of JNK inhibitors associated with activation of neural stem cells of brain were shown on the model of encephalopathy. An algorithm
and approaches for estimating the potential efficiency and many-sided selectivity of the modifiers of signaling molecules activity as
targeted hemostimulators were developed. The effectiveness of various targeted pharmacological agents determined by the selective
effect on different types of regenerative-competent cells was demonstrated on the models of cytostatic myelosuppression of various
genesis. The perspective of using intracellular signaling molecules in regenerative-competent cells as targets of drugs for regenerative
medicine was shown.
zgn@pharmso.ruPharm Anal Acta 2018, Volume: 9
DOI: 10.4172/2153-2435-C2-037