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Pharmaceutica Analytica Acta | Volume: 09
September 20-22, 2018 Prague, Czech Republic
Pharmaceutics & Drug Delivery Systems
17
th
Annual Congress on
Applications of supercritical fluids in the pharmaceutical industry
Irena Zizovic
1
and
Stoja Milovanovic
2
1
Wroclaw University of Science and Technology, Poland
2
University of Belgrade, Serbia
T
he advantageous and tunable properties of supercritical fluids being high densities, high diffusivities, low viscosities and near zero
surface tension, make them unique and applicable in many areas. In this presentation, new promising applications of supercritical
carbon dioxide in the pharmaceutical industry will be demonstrated, with the focus on the development of novel drug delivery
systems. Besides incorporation of drugs into polymers and composites, supercritical fluid applications offer possibilities of tailoring
the properties of the final product (e.g., pore size distribution), control of the active substance loading and consequently obtaining
diverse drug release kinetics. Examples of development of polymer-based materials for the controlled release of active components
by supercritical solvent impregnation of polymers with pure compounds or plant extracts, polymer foaming and impregnation in
supercritical carbon dioxide and fabrication of solid dispersions of drugs in polymers by processing with supercritical carbon dioxide
will be presented. A brief overview of other applications of interest for the pharmaceutical industry, like fractionation of natural
bioactive components, particle design and drug formulation will be provided as well.
irena.zizovic@pwr.edu.plPharm Anal Acta 2018, Volume: 9
DOI: 10.4172/2153-2435-C2-037