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conferenceseries.com
Volume 7, Issue 3 (Suppl) J Gastrointest Dig Syst, an open access journal
ISSN: 2161-069X Gastro 2017
June 12-13, 2017
June 12-13, 2017 Rome, Italy
11th Global
GastroenterologistsMeeting
Non-invasive assessment of liver fibrosis and steatosis
Wai-Kay Seto
The University of Hong Kong, Hong Kong
Liver biopsy has long been an imperfect gold standard for the assessment of liver fibrosis. While liver biopsy is still widely considered
in the disease assessment of viral hepatitis and non-alcoholic steatohepatitis, its invasive nature means it is seldom used to assess
treatment response in stable and asymptomatic patients. Non-invasive methods of liver fibrosis are gradually emerging. Serum-
based markers e.g. enhanced liver fibrosis score have been shown to correlate strongly with actual histology for multiple chronic
liver diseases. Another method of assessing is liver stiffness measurements via transient elastography, a non-invasive ultrasound-
based method that is easily performed with high reproducibility. Liver stiffness measurements have been well-validated in chronic
hepatitis B, chronic hepatitis C and non-alcoholic fatty liver disease. In addition, liver stiffness measurements have been shown to
have prognostic value on the development of cirrhotic complications, hepatocellular carcinoma and all-cause mortality. Evidence
on the role of liver stiffness measurement in the clinical monitoring of treatment response is also emerging. Transient elastography
also allows the measurement of controlled attenuation parameter, a quantitative marker of steatosis. Transient elastography is now
recommended by multiple international guidelines as an assessment tool for chronic liver diseases. There are also other methods of
liver fibrosis assessment, e.g. magnetic resonance imaging-based methods that are currently in development.
Biography
Wai-Kay Seto completed his Medical degree in 2003 and Doctor of Medicine in 2012. He is currently a Clinical Associate Professor in Department of Medicine
at University of Hong Kong. He is also a fellow in Gastroenterology and Hepatology and Consultant of Medicine at University of Hong Kong-Shenzhen Hospital,
Shenzhen, China. He has published more than 100 peer-reviewed articles in high-impact peer-reviewed journals, including first-authored articles in Journal of
Clinical Oncology, Gut, Hepatology, Journal of Hepatology and American Journal of Gastroenterology. He has been awarded numerous research awards by Hong
Kong College of Physicians.
Wai-Kay Seto, J Gastrointest Dig Syst 2017, 7:3(Suppl)
DOI: 10.4172/2161-069X-C1-049