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Volume 7, Issue 3 (Suppl)

J Gastrointest Dig Syst, an open access journal

ISSN: 2161-069X

Gastro 2017

June 12-13, 2017

June 12-13, 2017 Rome, Italy

11

th

Global

GastroenterologistsMeeting

Ulcerative colitis associated colorectal cancer patients who receives colorectal surgery more likely receive

blood transfusion and parental nutrition than Crohn’s disease associated colorectal cancer patients - A

propensity match study

Cheng Zhang

Ohio State University, USA

Introduction &Aim

: The health care resource utilization of inflammatory bowel disease (IBD)-associated CRC patients who undergo

colorectal surgery is unknown. Aim of this study was to compare the health care resource utilization, particularly the requirements

of blood transfusion and parental nutrition, between ulcerative colitis (UC)-associated colorectal cancer (CRC) and CD-associated

CRC who receives colorectal surgery.

Methods

: This was a cross-sectional study using data from the Nationwide Inpatient Sample. UC- or Crohn’s disease (CD)-related

and CRC-related hospitalizations that underwent colorectal surgery between 2008 and 2012 were identified using appropriate ICD-9-

CM codes. Exclusion criteria included: Age<18 years; carrying discharge diagnosis of both ulcerative colitis and Crohn’s disease (CD);

CD with small intestine involvement only and; patients with missing data among the variables of interest. The health care resource

utilization, including receiving blood product and parental nutrition was compared between UC-associated and CD-associated CRC

patients who underwent colorectal surgery. Statistical analysis: A propensity match study was used to compare the outcomes between

these two groups.

Results

: There were a total of 197 pairs of patients in each UC-associated CRC and CD-associated CRC group and they matched

well with respect to demographics, comorbidities, and institutional characteristics. We performed McNemar’s tests for categorical

variables in the matched sample. UC-associated CRC patients who receive colorectal surgery more likely receive blood transfusion

(p=0.0039) and parental nutrition (p=0.0203) when compared with CD-associated CRC patients (Table 1). In addition, the CRC

location is also different between UC- and CD-associated CRC (p=0.0006). More CD-associated CRC patients have right-sided colon

lesions. CD-associated CRC patients more likely received partial colectomy than UC-associated CRC patients (p<0.0001) (Table 2).

Discussion

: Inflammatory bowel disease (IBD) is associated with an increased risk of CRC. In contrast to sporadic CRC, IBD-

associated CRC is frequently diagnosed at a more advanced stage and tumors are often multiple and poorly differentiated. Because

UC and CD have different pathophysiology, subsequently, the phenotype and response to treatments including colorectal surgery

between UC- and CD-associated CRC would be different. Our study is the first to examine the health care resource utilization in

UC- and CD-associated CRC who receives colorectal surgery. Colorectal surgery in UC-associated CRC patients has been associated

with higher health care resource utilization, including blood transfusion and parental nutrition, when compared with CD-associated

CRC. In addition, the location and type of colorectal surgery are also different between these two groups. This study suggested that the

surgical treatment for UC- and CD-associated CRC is different and therefore, care of IBD-associated CRC around colorectal surgery

should be treated differently between UC and CD patients.

Biography

Cheng Zhang completed his MD at Hunan Medical University in China in 1995. After he completed his PhD in the field of Molecular Biology at University of Southern

California in 2005, he completed his Medicine Residency training at Greater Baltimore Medical Center affiliated to the Johns Hopkins University in Baltimore in 2009

and Gastroenterology fellowship training at Beth Israel Deaconess Medical Center, Harvard Medical School, in Boston in 2012. Now, he is an Assistant Professor at

Ohio State University in Columbus, Ohio. He is also a fellow of American College of Gastroenterology (ACG). His clinic interest is on Inflammatory Bowel Disease

(IBD) and his research is focused on IBD outcome research and IBD translational research, including JAK-STAT signaling pathway in IBD. He has numbers of

peer-peer reviewed publications, oral presentations in multiple international conferences, and many awards from gastroenterology associations.

zhang.4567@osu.edu

Cheng Zhang, J Gastrointest Dig Syst 2017, 7:3(Suppl)

DOI: 10.4172/2161-069X-C1-049