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Volume 8 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Gastro Congress 2018
August 20-21, 2018
August 20-21, 2018 | Rome, Italy
13th Euro-Global
Gastroenterology Conference
Noninvasive prediction of portal hypertension and liver fibrosis
Edlira Elezaj1 and Adriana Babameto2
1University Hospital Mother Tereza, Albania
2University Medical Center of Tirana Mother Teresa, Albania
Portal hypertension (PH) is responsible for most of the complications that mark the transition from compensated to
decompensated cirrhosis, namely variceal hemorrhage, ascites and hepatic encephalopathy. Due to the invasiveness,
requirement for advanced technical expertise and high costs associated with HVPG measurements, the introduction of simple,
noninvasive screening and diagnostic methods would represent a great clinical advancement. The aim of this work is to evaluate
the diagnostic efficacy of noninvasive liver fibrosis indexes in the diagnosis of PH. This is a prospective study conducted in
the period 2012-2016 including 87 cirrhotic patients. These patients are admitted in the Department of Gastrohepatology
at University Medical Center of Tirana Mother Teresa in Tirana and also followed at the policlinic specialities in Tirana. A
multivariate logistic model of serum markers showed that AST-to-platelet (PLT) ratio index (APRI), AAR (AST/ALT ratio),
Fib-4, fibrosis index (FI) were associated with PH. Also portal blood flow was measured and upper endoscopy was performed.
Actually they couldn’t undergo hepatic venous pressure gradient (HVPG) evaluation. For the diagnosis of cirrhosis AUCs
were 0.879 and 0.851 for APRI and FIB-4 respectively and predicted the presence of clinically significant portal hypertension
(CSPH), with the highest PPV (94%) and (93.3%). No significant difference was found between them and ROC curve for Echo
Doppler (pairwise comparison of ROC APRI ~ Echo_Doppler p=0.8 curves, Echo_Doppler ~ Fib_4 p=0.5). Noninvasive liver
fibrosis indexes could be used not only as a first-line screening method for CSPH but also for predicting esophageal varices
(EV) in cirrhotic patients as well as proxy for fluxmetric measurement.
Biography
Edlira Elezaj is a Gastrohepatologist in department of Gastrohepatology at University Hospital Mother Tereza, Tirana, Albania since the year 2005. Her occupational
skills in General medicine was covered at University of Tirana. From 1998- 2005 her specialization course in Gastro Hepatology, Abdominal Exercise, Digestive
Endoscopy were persued at the same university, University of Tirana. She is curently pursuing PhD on Noninvasive evaluation of portal hypertension. She is having
16 years of experience as Gastro-hepatologist from Regional Health Authority of Tirana, Polyclinic of Speciality No.2 and Tirana Continental Hospital. She was
invited to many conferences and is Authoring 20 referral articles.
Edlira Elezaj et al., J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C5-077