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conferenceseries.com
Volume 5, Issue 4 (Suppl) Occup Med Health Aff
ISSN: 2329-6879 OMHA, an open access journal Health Congress 2017
October 16-17, 2017
October 16-17, 2017 Dubai, UAE
12th World Congress on
Industrial Health, Healthcare and Medical Tourism
Near absence of clinical trial registry searching in open access systematic reviews in physical therapy:
The case of low back pain rehabilitation
Alaa S Abou Khzam
Lebanese University, Lebanon
Statement of the Problem: Clinical trial registries (CTR) fail in comparison with major databases. However, the registration
of trials promotes transparency and reduces risk of publication bias. Many previous studies have shown that searching CTR
for systematic reviews (SRs) is not present on a consistent basis. No analysis exists evaluating the extent of employing a search
strategy targeting CTR in open access SRs studying the effectiveness of physical therapy interventions on low back pain (LBP).
Methodology & Theoretical Orientation: PubMed was searched from 01/01/2010 to 31/12/2016 using search terms
physical therapy or rehabilitation and low back pain. The search was filtered to free full text and systematic reviews. The
analysis considered SRs that investigated the effectiveness of a specific physical therapy treatment (including all interventions
consisting of movement, posture, physical agents, mobilization and manipulation) on the pain and/or disability of patients
with LBP. Included reviews’ methods will be analyzed for the presence of CTR search. CTR accounted for in this analysis
includes metaRegister of controlled trials (mRCT), clinicaltrials.gov. and 17 primary clinical trial registries identified on the
International Clinical Trial Registry Platform (ICTRP) of the World Health Organization (WHO).
Results: Among the 147 yielded results, 43 SRs were included in the analysis. After the careful inspection of the search
methodology of each of the included SRs, only two (~4.65%) searched at least one of the CTR. One of which admitted to but
did not disclose the record resulted from searching CTR and excluded trials with missing data while the other retrieved 27
results searching mRCT and contacted authors of trials in case of missing data.
Conclusion: Searching CTR for SRs studying the effectiveness of physical therapy treatment on low back pain is clearly
neglected. Future reviewers of this subject are urged to consider searching CTR.
References
1.Baudard M, Yavchitz A, Ravaud P, Perrodeau E, Boutron I (2017) Impact of searching clinical trial registries in systematic reviews of pharmaceutical treatments: methodological
systematic review and reanalysis of meta-analyses. BMJ: j448.
2.Glanville J M, Duffy S, McCool R, Varley D (2014) Searching ClinicalTrials.gov and the International Clinical Trials Registry Platform to inform systematic reviews: what are the
optimal search approaches? Journal of the Medical Library Association; 102(3): 177-183.
3.Jones C W, Keil L G, Weaver M A, Platts-Mills T F (2014) Clinical trials registries are under-utilized in the conduct of systematic reviews: a cross-sectional analysis.
; 3: 126.
Angelis C, Drazen J M, Frizelle F A, et al. (2004) Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Canadian Medical
Association Journal. 2004; 171(6): 606-607.
5.Simes R J (1986) Publication bias: the case for an international registry of clinical trials. Journal of Clinical Oncology ; 4(10): 1529-41.
Biography
Alaa S Abou Khzam has completed his BS in Physical Therapy from the Lebanese University, Faculty of Public Health. His research interests include
neurorehabilitation, healthcare research methodology, motor control and motor learning.
Alaa S Abou Khzam, Occup Med Health Aff 2017, 5:4 (Suppl)
DOI: 10.4172/2329-6879-C1-038