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Journal of Infectious Diseases and Therapy ISSN: 2332-0877 | Volume: 6
Infectious Diseases
4
th
Annual Congress on
Neglected Tropical & Infectious Diseases
5
th
International Conference on
August 29-30, 2018 | Boston, USA
&
Absolute eosinopenia as a surrogate marker for enteric fever
Swati Kapoor, Rajeev Upreti, Monica Mahajan, Abhaya Indrayan
and
Dinesh Srivastava
Max Super-speciality Hospital, India
E
nteric Fever is caused by gram-negative bacilli
Salmonella typhi
and
para-typhi
. It is associated with high morbidity and mortality
worldwide. Timely initiation of treatment is a crucial step for the prevention of any complications. Cultures of body fluids are
diagnostic, but not always conclusive or practically feasible in most centers. Moreover, the results of cultures delay the treatment
initiation. Serological tests lack diagnostic value. The blood counts can offer a promising option in diagnosis. A retrospective study
to find out the relevance of leucopenia and eosinopenia was conducted on 203 culture proven enteric fever patients and 159 culture
proven non-enteric fever patients in a tertiary care hospital in New Delhi. The patient details were retrieved from the electronic
medical records section of the hospital. Absolute eosinopenia was considered an absolute eosinophil count (AEC) of less than 40 /
mm3 (normal level: 40-400/mm3) using LH-750 Beckman Coulter Automated machine. Leucopoenia was defined as total leucocyte
count (TLC) of less than 4 X 109 /l. Blood cultures were done using BacT/ALERT FA plus automated blood culture system before first
antibiotic dose was given. Case and control groups were compared using the Pearson Chi-square test. It was observed that absolute
eosinophil count (AEC) of 0-19 /mm3 was a significant finding (p<0.001) in enteric fever patients, whereas leucopenia was not a
significant finding (p=0.096). Using Receiving Operating Characteristic (ROC) curves, it was observed that patients with both AEC
<14/mm3 and TCL <8 x 109/l had 95.6% chance of being diagnosed as enteric fever and only 4.4% chance of being diagnosed as non-
enteric fever. This result was highly significant with p<0.001. This is a very useful association of AEC and TLC found in enteric fever
patients of this study which can be used for the early initiation of treatment in clinically suspected enteric fever patients.
swatikapoor3012@gmail.comJ Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C3-045