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Volume 7
Journal of Metabolic Syndrome
ISSN : 2167-0943
Metabolic Syndrome 2018 | Endoscopy 2018
June 28-29, 2018
Page 23
conference
series
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ENDOCRINOLOGY AND METABOLIC SYNDROME
&
ABDOMINAL IMAGING AND ENDOSCOPY
June 28-29, 2018 Amsterdam, Netherlands
12
th
International Conference on
3
rd
International Conference on
JOINT EVENT
Hidekatsu Yanai, J Metabolic Synd 2018, Volume 7
DOI: 10.4172/2167-0943-C1-007
Effects of Non-Exercise Activity Thermogenesis (NEAT) on metabolic parameters in patients with
type 2 diabetes
N
on-Exercise Activity Thermogenesis (NEAT) is the energy expenditure due to Physical Activities (PA) besides sports-like
exercise and resistance training. It includes various activities in daily life such as going to work, attending school, and
singing, dancing, washing clothes and cleaning floors. We developed the original questionnaire to evaluate NEAT in Japanese
people, based on 2011 Compendium of Physical Activities produced by American College of Sports Medicine, by considering
Japanese life-style and culture. The questionnaire consisted of 11 question items about locomotive activities and 25 question
items about non-locomotive activities. We evaluated each questionnaire item with a score of 1 to 3 points in order of levels of
daily PA and then added up the scores to determine the NEAT score. In our previous study using 45 subjects (22 women and
23 men) with type 2 diabetes who did not take any hypoglycemic, anti-hypertensive, or cholesterol-lowering agents, the NEAT
score was negatively correlated with serum insulin levels (r= -0.42, P<0.05). The NEAT score was also negatively correlated with
waist circumference (r= -0.509, P<0.05) and positively correlated with HDL-C levels (r = 0.494, P<0.05) in women, and was
negatively associated with serum insulin levels (r= -0.732, P<0.005), systolic (r= -0.482, P<0.05) and diastolic blood pressure
(r= -0.538, P<0.05) in patients with abdominal obesity. Our study demonstrated that NEAT is associated with amelioration in
insulin sensitivity, waist circumference, HDL-C, blood pressure, in patients with type 2 diabetes. We examined the validity of
our NEAT questionnaire by comparing with objectively measured daily PA by using the triaxial accelerometer. The NEAT score
was significantly and positively correlated with PA Level (PAL) measured by the triaxial accelerometer (r=0.604, P<0.001). PAL
was also significantly and positively correlated with both the locomotive NEAT score and the non-locomotive NEAT score
(r=0.444, P=0.001 and r=0.526, P<0.001, respectively). The NEAT score measured by the self-reported questionnaire was
highly correlated with PAL measured by the triaxial accelerometer. In type 2 diabetic women, the NEAT score was significantly
and negatively correlated with Urinary Albumin Creatinine Ratio (UACR) (r=-0.513, P<0.05) and positively correlated with
coefficient of variation of R-R intervals (CVRR) (r= 0.471, P<0.05). 5 Our study suggested that NEAT is beneficially associated
with markers for diabetic nephropathy and neuropathy in type 2 diabetic women. In patients with type 2 diabetes, multiple
regression analysis, adjusted for age, gender, height and weight, revealed that hand grip strength was positively associated
with total NEAT scores and locomotive NEAT scores. I summarized beneficial effects of NEAT on metabolic parameters. An
increase of NEAT enhances muscle strength, reduces visceral adiposity and blood pressure, and improves insulin resistance
and serum lipids, and is associated with lower risk of diabetic complications.
Biography
Hidekatsu Yanai is a Fellow ofAmerican College of Physicians (FACP), the Director of the Department of Internal Medicine and Clinical Research and Trial Center, National
Center for Global Health and Medicine Kohnodai Hospital, Japan. He is also the Professor of Wayo Women’s University, Japan. He obtained his MD and PhD degrees
in National Defense Medical College and Hokkaido University School of Medicine, respectively. He studied as Invited PhD Research Fellow in the National Institutes of
Health (NIH), USA. He is the Editor-in-Chief of
Journal of Endocrinology and Metabolism
and also an Editorial Board Member of 10 medical journals. He has 195 published
English papers in refereed medical journals.
dyanai@hospk.ncgm.go.jpHidekatsu Yanai
National Center for Global Health and Medicine, Japan