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conferenceseries.com
February 20-21, 2017 Berlin, Germany
9th International Congress on
Nutrition & Health
Volume 7 Issue 1 (Suppl) J Nutr Food Sci
ISSN:2155-9600 JNFS, an open access journal Nutrition & Health 2017
February 20-21, 2017 Berlin, Germany
Regulation of NF-κB by dietary curcumin in ovarian cancer
Kazim Sahin1, Cemal Orhan1, Mehmet Tuzcu1, Nurhan Sahin1, Hakki Tastan2, Ibrahim Hanifi Ozercan1, Osman Guler3, Nermin Kahraman4, Omer Kucuk5 and
Bulent Ozpolat4
1Firat University, Turkey
2Gazi University, Turkey
3Veterinary Control Research and Institute, Turkey
4University of Texas, USA
5Emory University, USA
Ovarian cancer is the most lethal gynecological cancer with 30% 5-year survival rate. High mortality rate is attributed to lack
of early diagnostic tests and effective curative therapeutic regimens. Curcumin, a polyphenolic compound found in turmeric
products, has been shown to be associated with reduced cancer incidence in populations consume high turmeric in their diet. Nuclear
factor kappa B (NF-κB) signaling is currently recognized as a useful strategy in cancer treatment and prevention. However, a direct
link between curcumin intake and regulation of NF-κB in ovarian cancer is yet to be established. Here, we investigated the effect of
daily dietary curcumin intake on the NF-κB pathway of spontaneous ovarian cancer in a hen model, the only non-human animal
that spontaneously develops cancer with a high prevalence. At the end of 12 months, the analysis of the tumors revealed that NF-
κB signaling were significantly inhibited by curcumin intake in a dose-dependent manner (P<0.05). In conclusion, the results of
our study demonstrated for the first time that daily curcumin intake leads to a significant and dose-dependent inhibition of NF-κB
signaling in the development of spontaneous ovarian cancer indicating a tremendous role of curcumin as a chemo preventive strategy
against ovarian cancer.
J Nutr Food Sci 2017, 7:1 (Suppl)