nutrition-congress-2018-keynote

13 / 13

Volume 8 Journal of Nutrition & Food Sciences
ISSN: 2155-9600 Nutrition Congress 2018
June 11-13, 2018
Page 67
Notes:
conferenceseries.com
June 11-13, 2018 | Dublin, Ireland
21st European
Nutrition and Dietetics Conference
Conor P Kerley, J Nutr Food Sci 2018, Volume 8
DOI: 10.4172/2155-9600-C3-058
Dietary nitrate: Novel, innovative roles in common, diverse cardiometabolic disorders
Statement of the Problem: Despite medical advance, cardiometabolic pathologies, including cardiac and respiratory diseases
are major causes of premature morbidity and mortality worldwide. Cost effective, safe and sustainable therapies are urgently
required. Nitric oxide (NO) is a potent vasodilator. NO synthesis can be facilitated in vivo by reduction of dietary nitrate (NO3-)
to NO independent of NO synthase, possibly providing therapeutic effect. Multiple cardiometabolic pathologies are associated
with perturbations in NO, including hypertension (HTN) and obstructive sleep apnoea syndrome (OSAS). To extend findings
from our preliminary studies (1,2), we hypothesized that dietary NO3- may have utility in HTN and OSAS. We conducted 2
separate double-blind, randomized, placebo-controlled, crossover trials of daily NO3- supplementation (concentrated beetroot
juice) compared to placebo (PL; matching nitrate-depleted beetroot juice) for 14d among a group of well-characterized, treated yet
uncontrolled hypertensives(3) and subjects with newly diagnosed OSAS(4). We recruited 20 uncontrolled hypertensives (mean
age=63y, mean BMI=31kg/m2, mean no. of antihypertensives=2) as well as 12 adults with severe OSAS (mean apnoea-hypnoea
index=74, mean age=52y, mean BMI=31kg/m2). Assessments were conducted on three occasions, baseline (day 1), midpoint,
(day 15) and endpoint (day 29) - before and after each intervention period and included plasma nitrate as well as 24h ambulatory
blood pressure. Daily dietary nitrate was well-tolerated, safe, led to increased plasma NO metabolites and decreased BP profiles
in uncontrolled hypertensives and OSAS. Dietary nitrate has potential as a novel therapeutic, adjunct strategy in difficult to treat
BP.. In a review review, we wrote that ‘increased green vegetables consumption may provide similar/ superior benefits to nitrate
supplementation in a cheaper, safer, and potentially tastier context’ (5). Considering the low cost and safety profile of foods
containing dietary nitrate, this concept appears promising as an adjunct therapeutic strategy for elevated blood pressure.
Biography
Conor P Kerley has his expertise in chronic disease prevention and treatment. He received his Bachelor’s degree in Human Nutrition and Dietetics from Trinity College
Dublin and his PhD from University College Dublin. He has presented his award winning findings at multiple national and international nutrition and medical conferences.
His research has been published in international peer-reviewed medical journals and has attracted over €210,000 in research funding to date In addition to his clinical
research, He served as chairperson of the Scientific and Research Steering Group of the Irish Nutrition and Dietetics Institute and is an active member of several
professional societies including the Irish Nutrition and Dietetics Institute, Nutrition Society, The National Blood Pressure Council and The True Health Initiative. The current
work is based on his design and implementation of a novel, innovative nutrition education intervention in addition to an exercise focused rehabilitation program.
Conor P Kerley
Dublin City University, Ireland