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Volume 8 Journal of Nutrition & Food Sciences
ISSN: 2155-9600 Nutrition Congress 2018
June 11-13, 2018
Page 42
conferenceseries.com
June 11-13, 2018 | Dublin, Ireland
21st European
Nutrition and Dietetics Conference
Kenneth Olson, J Nutr Food Sci 2018, Volume 8
DOI: 10.4172/2155-9600-C3-059
Diet-induced postprandial inflammation: Consequences on human health
Statement of the Problem: After ingesting a meal, postprandial inflammation occurs transiently and may have significant negative
consequences on human health. Postprandial inflammation is dependent on the food quality and quantity in terms of its energy
content and its nutritional value. Minerals and vitamins constitute the nutritional value while carbohydrate, protein and fat are the
sources of energy content.
Objective: Since energy content varies significantly between carbohydrates (4 kcal/g) and fats (9 kcal/g), the objective is to assess
postprandial inflammation of an isocaloric, isonitrogenous high carbohydrate (66%) and low fat (20%) diet (HC) versus a high fat
(56%) and low carbohydrate (30%) diet (HF) by measuring diet-induced postprandial thermogenesis (DIPT) and inflammation.
Methodology: Healthy, never-obese, postmenopausal, Caucasian female subjects (n=12) participated in this study for 3 weeks each
in a crossover design. Fat-Free Mass (FFM) and Fat Mass (FM) were measured by under-water weighing before and after each diet
exposure. Resting Metabolic Rate (RMR) was assessed fasting and for five 40-minute periods over a 6 hours DIPT after ingesting
14.3 kg/FFM of either HC or HF diet.
Results: A low Respiratory Quotient (RQ) is usually indicative of lipid peroxidation, an important index of inflammation, measured
in this study as TBARS (Thiobarbituric Acid Reacting Substances). RQ for HC diet was significantly higher than that of HF in this
study. A significant elevation of Free Fatty Acid (FFA) was also observed after ingesting HF diet, which is well-known to be associated
in the pathophysiology of Type 2 Diabetes Mellitus (T2DM), a significant risk factor for cardiovascular disease (CVD).
Conclusions & Significance: Postprandial inflammation is also intimately implicated with Glucotoxicity and Lipotoxicity as
displayed under the Image are well known to be associated with T2DM and CVD. Significant other related facts and figures will be
illustrated in the presentation.
Biography
Kenneth Olson, MD, PhD, is certified in Internal Medicine and in Clinical Nutrition. His PhD is in Nutrition Sciences. He has an active consulting practice of Nutritional
Medicine for 30 years in both hospital and outpatient settings. He has taught nutrition to medical students, dental students, postgraduate physicians and to dietitians as
well as community groups. He has published within the field of nutrition and in clinical medicine and animal research directed toward clinical applications. He previously
presented posters on Nutrition and AIDS at the National Institutes of Health and at similar meeting in Houston, Texas USA. He has collaborated with Mohammad
Khaled, PhD, for many years in the areas of diet composition and the functionality of food associated with clinical outcomes especially involving the immune system and
inflammatory processes.
Kenneth Olson
Life Sciences Technologies International, USA