obesity-meeting-2018-scientifictracks

14 / 14

Page 30
Notes:
conferenceseries.com
Volume 8 Journal of Obesity & Weight Loss Therapy Obesity Meeting 2018
August 24-25, 2018
August 24-25, 2018 Singapore
20th Global Obesity Meeting
Shiny E C Kachhap, J Obes Weight Loss Ther 2018, Volume 8
DOI: 10.4172/2165-7904-C6-072
Effect of dietary chitosan extracted from carapace of freshwater crab Sartoriana spinigera on body
weight, liver weight and food intake of hyper-cholesterolemic albino rats
Shiny E C Kachhap
Ranchi University, India
Obesity may be defined as a condition where over accumulation of fat occurs in adipocytes that might have a negative effect
on one’s health. Excess body weight due to uncontrolled eating habits leads to increased risk of many diseases. Treatment
of obesity is very costly, therefore, the present society demands for medicines of natural origin that can cure, rather prevent
obesity from developing. Chitosan is one such natural zoo-therapeutic medicine that is found in the exoskeleton of arthropods,
crustaceans. Chitosan, a cationic biopolymer has affinity towards anionic fatty acids and does not allow them to get deposited
in the body tissues and organs. In this experiment, Chitosan was extracted from carapace of Sartoriana spinigera, a locally
found freshwater crab of Jharkhand, India. The obtained chitosan was characterized by FTIR and degree of de-acetylation was
found to be 78.53%. 20 albino rats were divided into 4 groups: Group-A (normal diet), Group-B (high fat diet), Group-C (high
fat diet+5% chitosan) and Group-D (high fat diet+5% synthetic hypo-lipidemic drug). Parameters of body weight, liver weight
and food intake in all groups were measured after 30 days. Statistical analysis by student’s t test revealed that Group-C fed with
chitosan showed lower body weight gain than Group-B at 1% significance. Statistical analysis also showed that average food
intake of Group-C was least amongst all groups and was significantly lower than that of Group-B at 0.1%. The final liver weight
of rats was also found to be significantly lower in Group-C than Group-B at 0.1% level. Ultra-structural studies of hepatocytes
of different groups also confirmed that chitosan fed rats showed curing of pathological deformities observed in HFD fed rats.
The findings confirm that chitosan causes satiety and decreases body weight gain and liver weight, thereby preventing obesity.
Thus, chitosan extracted from Sartoriana spinigera should be encouraged as medicines against obesity.
Biography
Shiny E C Kachhap is currently pursuing her PhD in Zoology with special interest in the use of natural zoo-therapeutic sources that are ethno-biologically used by
tribal of Jharkhand, India and to establish the scientific significance of medicines acquired from such sources so as to acknowledge the society about utilization of
locally found species and encouraging the culture of such species that can financially support the farmers and cultures of the area. Attaining biopolymers from animal
sources and determining their use is also her interest of study. She is currently an Assistant Professor and has been contributing in teaching for more than 2 years.