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Volume 8
Journal of Obesity & Weight Loss Therapy
Obesity Meeting 2018
August 24-25, 2018
August 24-25, 2018 Singapore
20
th
Global Obesity Meeting
Nadezhda Bazhan et al., J Obes Weight Loss Ther 2018, Volume 8
DOI: 10.4172/2165-7904-C6-072
Fasting increases FGF21 expression in liver and changes gene expressions in metabolic organs in a
sex-specific manner in mice
Nadezhda Bazhan, Yakovleva T, Denisova E, Dubinina N, Feofanova N, Chepeleva E and Makarova E
Institute of Cytology and Genetics, Russia
F
asting is often used for obesity correction. Fibroblast Growth Factor-21 (FGF21) is a hormone secreted by the liver during
fasting that elicits diverse aspects of the adaptive fasting response. In mice, FGF21 is induced through a peroxisome
proliferator-activated receptor α (PPAR α)-dependent mechanism. It is unknown that whether fasting increases the FGF21
expression in the liver in a sex-specific manner. We found, that in females, 24 hours-fasting increased hepatic PPARα and
FGF21 gene expressions and blood FGF21 and adiponectin levels to a greater extent than in males. Fasting-induced changes
in hepatic expression of genes related to gluconeogenesis, glucose oxidation and fatty acid synthesis were the same in males
and females. In females, adaptation to fasting was associated with up-regulation of UCP3 and CPT1 expressions in muscle and
multidirectional changes in SLC2A4 gene expressions: Increased in muscle and decreased in visceral White Adipose Tissue
(WAT). In males, down-regulation of PPARγ in visceral and subcutaneous WAT was the only adaptation to fasting. Thus fasting
induced more pronounced increase in the FGF21 signaling and wider range of transcriptional responses in females compare
to males. These data can be taken into account when using fasting for body weight regulation. This study was supported by the
Russian Science Foundation, grant No 17-15-01036.
Biography
Nadezhda Bazhan is the Chief Researcher at the Institute of Cytology and Genetics, Russian Academy of Sciences and Professor of Novosibirsk State University.