pharma-middle-east-2018-scientifictracks

6 / 17

Page 27
Notes:
conferenceseries.com
Volume 5 Journal of Pharmaceutical Care & Health Systems Pharma Middle East 2018
November 05-07, 2018
November 05-07, 2018 Abu Dhabi, UAE
18th Annual
Pharma Middle East Congress
Hashem O Alsaab, J Pharma Care Health Sys 2018, Volume 5
DOI: 10.4172/2376-0419-C4-035
Multifunctional nanoparticles for cancer immunotherapy: An emerging approach for personalized
cancer therapy
Hashem O Alsaab
EACPHS Wayne State University, USA
S everal cancer immunotherapeutic approaches have been recently introduced into the clinics and they have shown
remarkable therapeutic potentials. The groundbreaking cancer immunotherapeutic agents function as a stimulant or
modulator of the body immune system to fight against or treat cancers. Although targeted immunotherapies such as immune
check point inhibitors (CTLA-4 or PD-1/PD-L1), DNA vaccination and CAR-T therapy are revolutionizing cancer treatment,
the delivery efficacy can be further improved while their off-target toxicity can be mitigated through nanotechnology
approaches. Nanomedicines can be multifunctional drug delivery agents for cancer therapies. However, they have faced several
challenges in clinical trials owing to poor targeting ability, insufficient tumor penetration, difficulty in synthesis and scale
up and limited understanding of interactions between a tumor and nanoparticles. In this regard, tumor multicomponent
targeting drug delivery systems are a rational approach for developing tumor-site-specific therapeutics. The nanoparticles
can be co-loaded with drugs, genes and imaging agents, surface decorated with varying targeting ligands that can home to
varying tumors and/or tumor multicomponent. Recent research has demonstrated that nanotechnology has multifaceted role
for (1) re-educating Tumor Associated Macrophages (TAM) to function as tumor suppressor agent, (2) serving as an efficient
alternative for Chimeric Antigen Receptor (CAR)-T cell generation and transduction and (3) selective knockdown of KRAS
oncogene addiction by nano-Crisper-Cas9 delivery system. The function of host immune stimulatory signals and tumor
immunotherapies can further be improved by repurposing of nanomedicine platform. This presentation will summarize the
role of multifunctional polymeric, lipid, metallic and cell-based nanoparticles for improving current immunotherapy.
Biography
Hashem Alsaab has completed his PhD from Dr. Iyer’s group in U-BiND Systems Laboratory, Department of Pharmaceutical Sciences, EACPHS Wayne State
University, USA and Pharmacy (PharmD) and Master of Science in Pharmaceutical Sciences-Industrial Pharmacy option from University of Toledo, OH, USA.
He is currently working as an Assistant Professor of Pharmaceutics and Pharmaceutical Technology, Taif University, Saudi Arabia. He is a Research Scientist
with a demonstrated history of working in the higher education and clinical practice. He is skilled in pharmaceutical sciences, cancer research, drug delivery,
nanotechnology and biotechnology.