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.com
Volume 8
Journal of Clinical Trials
Pharmacy and Pharmacovigilance 2018
July 16-17, 2018
July 16-17, 2018 Sydney, Australia
Joint Event on
Global Pharmacovigilance and
Advanced Pharmacy
Levofloxacin loaded nano-niosomes for controlled release ocular drug delivery
Balqees Saeed Hazaa, Ahmed Abd El-Bary and Howida Kamal Ibrahim
Cairo University, Egypt
T
he current study aimed to increase ocular residence time of levofloxacin by formulation into controlled release nano-niosomes for
once daily administration. Levofloxacin loaded niosomes were prepared by the film hydration technique with aid of sonication,
utilizing either chloroform or dichloromethane as a solvent, methanol as a co-solvent, span 60 as a surfactant; cholesterol as a
surfactant-additive agent; Dicetyl Phosphate (DCP) as a charge inducer. Nine niosomal formulae were prepared and characterized
for Entrapment Efficiency (EE%), morphological features, Particle Size (PS), Polydispersity Index (PDI), Zeta Potential (ZP), pH and
in vitro
release. Based on the results of these studies, certain formula was further investigated for its morphology using transmission
electronic microscopy; sterilization using gamma-irradiation; stability upon storage;
in vivo
evaluation. The selected nano-niosomal
formula showed good EE% and was found to be stable upon storage after being exposed to sufficient doses of gamma-irradiation.
In
vivo
testing of the selected formula showed that the niosomes extended levofloxacin release up to 24 hours without causing any ocular
irritation. This formula exhibited superior microbiological activity compared to the commercial eye drops.
Yemenceutics@gmail.comJ Clin Trials 2018, Volume 8
DOI: 10.4172/2167-0870-C2-026