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Volume 8, Issue 4 (Suppl) J Vet Sci Technol, an open access journal
ISSN: 2157-7579 Veterinary 2017
September 04-05, 2017
September 04-05, 2017 | Paris, France
7th International Veterinary Congress
Quorum sensing in Pseudomonas aeroginosa
Belgin Siriken1 and Veli Oz2
1Ondokuz Mayis University, Turkey
2General Directorate of Agricultural Research and Policies, Turkey
P. aeruginosa is most well-known as a biofilm-forming bacterium. It is an opportunistic pathogen and majority of the infections
are commonly associated with nosocomial infection and infection in immunocompromised hosts. Infections with P. aeruginosa
are difficult to eradicate, due to their high levels of antibiotic resistance and growth in biofilms. Production of secondary metabolites
is controlled by a cell-cell signaling system that is generally described as quorum sensing (QS) or density-dependent gene regulation.
QS, bacterial cells send a small diffused signal molecule called autoinducer (AI) to the next bacterial cells for the biofilm formation,
and the bacteria contact each other for stimulation and interaction with other bacteria. For this reason, extracellular signals and QS
regulation system is very important for presence of biofilm, and it has been considered an attractive target for the development of
new treatment strategies. QS regulation in the P. aeruginosa is controlled by at least two pairs of gene [LasI (LasI/lasR) - RhII (RhlI/
RhlR)], coded N-acylated homoserine lactones. LasI and RhII genes are stimulate the signal molecules. While LasI codes N-(3-
oxododecanoyl) homoserine lactone (3O-C12-HSL) which is a AI sentase, RhII codes the N-butyryl homoserine lactone (C4-HSL).
As there is a rise of the bacterial population, these signal molecules are produced and saved by P. aeruginosa and transcriptional
regulators come from the same origin for activation and binding of these molecules, intracellular concentration triple as soon as
short time. LasI and RhI systems regulate the virulence factors such as elastase, alkaline phosphatase, hydrogen cyanide, exotoxin
A, secretor proteins, catalase, rhamnolipid, pyosiyanine, lectins, acylated homoserin lactones (AHLs) and superoxide dismutase
production. The third gen couple which helped in regulating QS is PQS-MvfR. The expression of PQS depends on LasR, and Rh1R
gene increases in the expression. In conclusion obtained from findings, QS mechanism will make contributions to keep the lights
in medical area via improvements of treatment against the antibiotic-resistant P. aeruginosa and struggles with it in food processing
plant bacterial cells for the biofilm formation, and the bacteria contact each other for stimulation and interaction with the other
bacteria for this reason.
Biography
Belgin Sırıken is an expert in Food Microbiology, Safety and Chemical Properties of Particularly Animal Origin Foods. She has completed her PhD at Ankara
University, and now she is working as Prof. Dr. at Ondokuz Mayis University, Samsun, Turkey. Her focus is on Molecular Food Microbiology.
Belgin Siriken et al., J Vet Sci Technol 2017, 8:4(Suppl)
DOI: 10.4172/2157-7579-C1-024