world-biomarkers-pharma-biotech-2017-tracks

Notes:

Volume10, Issue 12 (Suppl)

J Proteomics Bioinform, an open access journal

ISSN: 0974-276X

Page 35

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World Biomarkers & Pharma Biotech 2017

December 07-09, 2017

December 07-09, 2017 | Madrid, Spain

International Conference on

PHARMACEUTICAL BIOTECHNOLOGY

WORLD BIOMARKERS CONGRESS

JOINT EVENT ON

Anticancer efficacy of self-nanoemulsifying drug delivery system of sunitinib malate

Saad M Alshahrani

Prince Sattam Bin Abdulaziz University, Saudi Arabia

unitinibmalate (SM) is reportedas aweakly solubledrug inwaterdue to itspoordissolutionrateandoral bioavailability.Hence,

in the current study, various “self-nanoemulsifying drug delivery systems (SNEDDS)” of SM were prepared, characterized

and evaluated for the enhancement of its

in vitro

dissolution rate and anticancer efficacy. On the basis of solubilization potential

of SM in various excipients, “Lauroglycol-90 (oil), Triton-X100 (surfactant) and Transcutol-P (cosurfactant)” were selected for

the preparation of SM SNEDDS. SM-loaded SNEDDS were developed by spontaneous emulsification method, characterized

and evaluated for “thermodynamic stability, self-nanoemulsification efficiency, droplet size, polydispersity index (PDI), zeta

potential (ZP), surface morphology, refractive index (RI), the percent of transmittance (% T) and drug release profile.”

vitro

dissolution rate of SM was significantly enhanced from an optimized SNEDDS in comparison with SM suspension. The

optimized SNEDDS of SM with droplet size of 42.3 nm, PDI value of 0.174, ZP value of −36.4 mV, RI value of 1.339% T value

of 97.3%, and drug release profile of 95.4% (after 24 h via dialysis membrane) was selected for

in vitro

anticancer efficacy

in human colon cancer cells (HT-29) by MTT assay. MTT assay indicated significant anticancer efficacy of optimized SM

SNEDDS against HT-29 cells in comparison with free SM. The results of this study showed the great potential of SNEDDS in

the enhancement of

in vitro

dissolution rate and anticancer efficacy of poorly soluble drug such as SM.

Saad M Alshahrani, J Proteomics Bioinform 2017, 10:12(Suppl)

DOI: 10.4172/0974-276X-C1-109