alexa Elevation of Serum Apolipoprotein B after Successful Eradication of Hepatitis C Virus in Patients with Chronic Hepatitis C Treated by IFNBased Therapy
ISSN: 2167-0889

Journal of Liver
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Research Article

Elevation of Serum Apolipoprotein B after Successful Eradication of Hepatitis C Virus in Patients with Chronic Hepatitis C Treated by IFNBased Therapy

Kogame M, Ishii K*, Kanayama K, Shinohara MI and Sumino Y
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University School of Medicine, Faculty of Medicine, Tokyo, Japan
Corresponding Author : Ishii K
Division of Gastroenterology and Hepatology
Department of Internal Medicine
Toho University School of Medicine
Faculty of Medicine, 6-11-1
Omorinishi, Otaku, Tokyo, 143, Japan
Tel: 81-3-3762-4151
Fax: 81-3-3763-8542
E-mail: [email protected]
Received March 21, 2012; Accepted August 29, 2012; Published August 31, 2012
Citation: Kogame M, Ishii K, Kanayama K, Shinohara MI, Sumino Y (2012) Elevation of Serum Apolipoprotein B after Successful Eradication of Hepatitis C Virus in Patients with Chronic Hepatitis C Treated by IFN-Based Therapy. J Liver 1:113. doi: 10.4172/2167-0889.1000113
Copyright: © 2012 Ishii K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Hepatitis C Virus (HCV) infection is closely tied to the lipid metabolism of liver cells. We recently reported that serum levels of LDL- and VLDL-cholesterol (Cho) increased in patients with Chronic Hepatitis C (CHC) showing Sustained Virologic Response (SVR) after treatment with interferon (IFN)-based therapy. LDL- and VLDLCho contained apolipoprotein (apo)-B synthesized in the liver as a major protein component. The goal of the present study was to clarify how serum lipid markers change in CHC patients showing SVR after treatment with IFN-based therapy. Patients and methods: The study included 121 consecutive patients with CHC infected with HCV genotype 1 (n=66, male/female: 40/26) or HCV genotype 2 (n=55, male/female: 38/17). Ninety-five patients received PEGIFN alpha and Ribavirin (RBV). Twenty-six patients received PEG-IFN alpha-2a alone. SVR was defined as being negative for serum HCV-RNA on RT-PCR at 24 weeks after the End of Therapy (EOT). Fasting serum triglyceride (T-G), total-Cho, and apo-B were evaluated before starting therapy and at 24 weeks after EOT. Results: SVR rates were 74% (90/121). Serum levels of total-Cho and apo-B increased significantly (p<0.05 by Wilcoxon test) in patients infected with HCV genotypes 1 and 2 who achieved SVR at 24 weeks after EOT, as compared to before the start of therapy, but no increases were seen in non-SVR patients. Conclusions: Infection with HCV genotypes 1 and 2 equally lowered serum levels of apo-B and total-Cho, which increased after HCV was successfully eradicated.

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