clinical-trials-2017-scientifictracks-abstracts

14 / 46

Page 47
Notes:
conferenceseries.com
Volume 7, Issue 5 (Suppl) J Clin Trials, an open access journal
ISSN:2167-0870 Clinical Trials 2017
September 11-13, 2017
September 11-13, 2017 San Antonio, USA
4th International Conference on
Cl inical Tr ial s
Cancer metastasis: Enactment of the script for human reproductive drama
Xichun Sun
Virginia Commonwealth University School of Medicine, USA
In parallel to the appearance of primordial germ cells during early embryogenesis, the cancer reproductive saga starts with
the separation of metastasis initiating cells (MICs) from cancer initiating cells when the primary cancer is still in its infancy.
Prime MICs embark on a journey to the host bone marrow where they undergo further development and regulation. Migrating
MICs are guided by the same CXCR4/CYCL12 axis as used in the migration of primordial germ cells to the genital ridge. Like
the ovary, the host bone marrow features immune privileges, coolness, hypoxia and acidity which are essential for stemness
maintenance and regulation. Opportune activation of the MICs via fusion with bone marrow stem cells triggers a frenzy of
cellular proliferation and sets them on the move again. This scenario is akin to oocyte fertilization in the fallopian tube and its
subsequent journey towards the decidum. Just as the human reproductive process is plagued with undesirable outcomes so is
the cancer metastasis highly inefficient. The climax of the cancer metastatic drama (colonization) is reached when proliferating
MIC clusters attempt to settle down on decidum-like premetastatic sites. Successfully colonized clusters blossom into overt
macrometastases only after the execution of sophisticated immunomodulation, angiogenesis and vascular remodeling.
Similarly, the implanted blastomere needs to orchestrate these feats before flourishing into a new life. What is more, the cancer
reproductive drama seems to be directed by a primordial Hypothalamus -Pituitary -Gonad axis. Pursuing this reproductive
trail could lead to new frontiers and breakthroughs in cancer research and therapeutics.
Biography
Xichun Sun is a practicing Surgical Pathologist and Cytopathologist. He graduated from medical school in China. He completed his PhD, Post-doctoral, Residency
Training and Fellowships in the USA. His current research interest centers about cancer diagnosis, carcinogenesis and cancer metastasis. He is the author of one
monograph and has proposed a new theory on cancer metastasis.
Xichun Sun, J Clin Trials 2017, 7:5 (Suppl)
DOI: 10.4172/2167-0870-C1-019