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Dementia 2016
September 29-October 01, 2016
Volume 6 Issue 5(Suppl) J Alzheimers Dis Parkinsonism 2016
ISSN:2161-0460 JADP, an open access journal
conferenceseries .com
September 29-October 01, 2016 London, UK
5th International Conference on
Alzheimer’s Disease & Dementia
Janice Hoffman, J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)
Trends of successful exelon (Rivastigmine) patch in geriatric patients with Dementia
Janice Hoffman
Western University of Health Sciences, USA
S kin reactions are one reason for termination of rivastigmine patch. The study goal was to identify factors associated with
skin reactions from rivastigmine patch in older adults. A retrospective chart review with prospective skin assessment
observational study was performed on all outpatients with Alzheimer’s dementia at a specialized ambulatory geriatric
evaluation clinic.
Demographic, clinical, and outcome variables were compared between the two groups (i.e., those with versus without
skin reactions) using χ2 or Fisher’s exact test for cross-tabulations of nominal variables and independent samples and Student
t-test, for continuous variables. Statistical differences between groups were considered significant when p-values were ≤ 0.05.
A total of 33 patients were included with 24.2% males, 75.8% females and a mean age of 83 years. Race included Caucasian
(90.9%) and Hispanic (9.09%). Patients lived at home with a spouse (39.39%), home with caregiver (24.24%) or in an assisted-
living facility (6.06%).
A statistically significant finding was MMSE score of 17 (p<0.01) and a skin reaction. Comorbidities included, 15.2% had
diabetes and 66.7% had hypertension. On average sodium plus potassium values were 139 mEq/L and 4 mEq/L respectively.
Bathing was on average 3 baths weekly. Concomitant medications included: memantine (39.4%), antidepressant (51.5%),
antipsychotic (12.1%) with 24.2% not taking any medications.
Two statistically significant skin reactions seen were erythema where the patch was applied and pruritis (p<0.01). There
were no significant skin reactions resulting in rivastigmine patch discontinuation.
This small cohort showed one statistically significant trend: the lower MMSE score the increase risk of a skin reaction.
Biography
Hoffman has completed her Pharm.D. from the University of Southern California, School of Pharmacy in Los Angeles, CA, USA and postdoctoral studies from
University of Maryland at Baltimore Mental Health System. She is the director of PGY-1 pharmacy residency in Geriatrics at the los Angeles Jewish Home for the
Aginig, and an Associate Professor at Western University of Health Sciences where she is the expert in nuerology. She has published more than 25 papers in
reputed journals and has been serving as an Associate Editor of the California Pharmacist Journal.