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Dementia 2016
September 29-October 01, 2016
Volume 6 Issue 5(Suppl) J Alzheimers Dis Parkinsonism 2016
ISSN:2161-0460 JADP, an open access journal
conferenceseries .com
September 29-October 01, 2016 London, UK
5th International Conference on
Alzheimer’s Disease & Dementia
Azza A Ali et al., J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)
The Role of Mental and PhysicalActivities against Development ofAlzheimer’s disease in Socialized
and Isolated Rats
Azza A Ali1, Mona G Khalil2, Hemat A Elariny1 and karema Abu-Elfotuh1
1Al-Azhar University, Egypt
2Modern University for Technology and Information, Egypt
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder; lifestyle changes may slow its onset
and progression. Mental and physical activities have been associated with better cognitive function in healthy older adults.
Cognitive engagement and physical activities have been associated with decreased risk of AD. Social isolation refers to a
complete absence of or insufficient contact with other members of society and can exacerbate memory deficits.
Objective: To study the influence of mental and physical activities in normal socialized conditions as well as to evaluate their
role in social isolated conditions on normal and AD rat models.
Methods: Rats were divided into two main groups; Group I socialized and Group II isolated. Both socialized and isolated
groups were subdivided into four subgroups; two received saline and served as control, while two served as AD subgroups
and received ALCl3 (70mg/kg IP) every day for four weeks. One of the control and AD subgroups was exposed to mental and
physical activities but the other not exposed. Mental and physical activities were performed using Swimming test and Y-maze
(each for one time/week) during four weeks. Isolated rats were housed individually in cages covered with black plastic while
socialized rats randomly paired and housed in transparent covered cages. Histopathological changes in different brain regions
and biochemical changes in Aβ, ACHE, brain monoamins (DA, NE, 5-HT), inflammatory mediators (TNF-α, IL-1β), oxidative
parameters; (MDA, SOD, TAC) as well as brain derived neurotrophic factor (BDNF) were also measured for all groups.
Results: Brain neurological damage characterizing isolation was more pronounced in isolation-associated AD rats. Mental
and physical activities significantly decreased Aβ, ACHE, MDA, TNF-α, IL-1β together with increased SOD, TAC, DA, NE,
5-HT and BDNF. The protective effect of mental and physical activities against brain neuronal degenerations was more marked
in isolated rats especially in isolated-associated AD rats. These results were confirmed by histopathological examinations of
different brain regions.
Conclusion: Mental and physical activities can protect from brain neuronal degenerations either induced by isolation or that
associated with AD in both socialized and isolated rat models. The protection using mental and physical activities is more
pronounced in isolation-associated AD model.
Biography
Azza A Ali has completed her PhD from Faculty of Pharmacy, Cairo University and postdoctoral studies from Faculty of Pharmacy, Al-Azhar University. She is the
Head of Pharmacology and Toxicology Department, Al-Azhar University, Egypt. She has published more than 35 papers in reputed journals and developed research
line in behavioral pharmacology in Egypt. She is member of many scientific societies in Egypt and of (AAPS) American Association of Pharmaceutical Scientists
(2002). She is interested in CNS degenerations and disorders especially AD and dementia and has many researches and publications on its causes, prevention
and risk factors especially stress and malnutrition. She is an Editorial Board Member at journal of Acta Psychopathologica.