dementia-2016_scientifictracks-abstracts

Notes:

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Dementia 2016

September 29-October 01, 2016

Volume 6 Issue 5(Suppl)

J Alzheimers Dis Parkinsonism 2016

ISSN:2161-0460 JADP, an open access journal

conferenceseries

.com

September 29-October 01, 2016 London, UK

International Conference on

Alzheimer’s Disease & Dementia

QI Xinyang, J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)

The projection from postrhinal cortex to ventral lateral orbitofrontal cortex impacts on spatial

memory

QI Xinyang

Southeast University, China

Background:

Over the past decades, great effort has been spending on research of Alzheimer disease (AD), many scientists

focus on the predictors of AD. Spatial memory deficits have been recognized in the early stages of AD, but have been studied

less[1]. The previous studies have shown a cloes relationship between spatial memory and postrhinal cortex (POR)[2], but

which projection from POR impacts on spatial memory is still to be found out. So with the help of optogenetics, we can do

further research.

Purpose:

To find out which projection from POR impacts on spatial memory.

Methods:

Using optogenetics to control neuron activity, using novel object recognition to test the spatial memory performance

of mice, using immunofluorescence of c-Fos to search the terminal cortex, choose 3-month C57BL/6 mouse.

Results:

In novel object recognition testing, when inhibiting glutamatergic neurons activity of POR in both study and

recognition phase, the spatial memory level of experimental group is lower than matched group (t=2.38, P<0.05); when

inhibiting glutamatergic neurons activity of POR only in study phase, there is no significant differences in both group (t=7.68,

P>0.05); when inhibiting glutamatergic neurons activity of POR only in recognition phase, the spatial memory level of

experimental group is lower than matched group (t=3.23, P<0.05). 1.5h after optical stimulation, immunofluorescence of c-Fos

shows that c-Fos positive neurons of ventral lateral orbitofrantal cortex (OFC) in experimental group is less than matched

group (t=2.87, P<0.05).

Conclusion:

The projection from POR to OFC impacts on the recognition phase of spatial memory via glutamatergic neuron.