dementia-2016_scientifictracks-abstracts

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Dementia 2016

September 29-October 01, 2016

Volume 6 Issue 5(Suppl)

J Alzheimers Dis Parkinsonism 2016

ISSN:2161-0460 JADP, an open access journal

conferenceseries

.com

September 29-October 01, 2016 London, UK

International Conference on

Alzheimer’s Disease & Dementia

Alaa Selim et al., J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)

The

in vivo

triad behind the neuromodulatory effect of

Bauhinia variegata

Alaa Selim, Heba Handoussa

and

Nesrine Elsayed

German University in Cairo, Egypt

PS is a well established model for induction of neuroinflammation and amyloidogenesis widely used to study the pathway

of many neurodegenerative diseases like Alzheimer’s disease. Phenolics are widely known for their different beneficial

characteristics, they could be considered as promising therapeutic agents against neurodegenerative diseases.

In this study, hydroalcohol extract of leaves and stalks of

Bauhinia variegata

has been shown to ameliorate neurodegenerative

diseases owing to the high phenolic content including flavonoids.

The effect of the plant was studied in a dose dependent manner in comparision to herbal (green tea) and non-herbal

reference (donepezil HCl) standards and the

in vivo

study was designed in what is promised to be the

in vivo

triad. The peak of

the triad was represented by improvement of cognitive performance in

in vivo

behavioural tests (Y maze and water maze). The

first side of the triad base was represented by biochemical analysis done on brain homogenates by ELISA where a recognizable

decrease in amyloid beta 42 was observed by 39.89%, 59.8%, 71.3% and 78.49% after administration of doses 50, 100, 200 and

400 mg/kg of the studied extract respectively in addition to an increase in SOD levels by 80%, 2.4 folds, 4.5 folds and 5.6 folds

after treatment with the same doses respectively.

The second side of the triad base was represented by histopathological investigation which confirmed the previous findings.

According,

Bauhinia variegata

could be considered as a phenolic capsule that can bombard and delay progression of

neurodegenerative diseases.