14 / 26
Page 89
Notes:
conferenceseries
.com
Volume 8, Issue 9 (Suppl)
J Clin Exp Cardiolog, an open access journal
ISSN: 2155-9880
Euro Cardiology 2017
October 16-18, 2017
October 16-18, 2017 | Budapest, Hungary
20
th
European
Cardiology
Conference
Lidia Capotosto et al., J Clin Exp Cardiolog 2017, 8:9(Suppl)
DOI: 10.4172/2155-9880-C1-078
Assessment of biventricular function in human immunodeficiency virus infection in adolescents and
young adults by three-dimensional speckle tracking echocardiography
Lidia Capotosto, Camilla Ajassa, Gabriella D’Ettorre, Nelson Cavallari, Maria Rosaria Ciardi, Vincenzo Vullo
and
Antonio Vitarelli
Sapienza University, Italy
Background:
The pathogenesis of left ventricular (LV) dysfunction in HIV patients includes cardiac direct effects of HIV, the
presence of autoantibodies, myocardial inflammatory response to viruses, other infections related to the immune status of
patients and side effects associated with antiretroviral drugs or other drugs used for the management of HIV. The purpose of our
study was to evaluate biventricular parameters of wall deformation with three-dimensional speckle tracking echocardiography
(3DSTE) in HIV-infected patients on antiretroviral therapy in order to detect a possible subclinical myocardial dysfunction.
Methods:
Sixteen patients aged 12 to 31years with human immunodeficiency virus infection and 16 normal controls of the
same age and sex was studied with 3DSTE. All patients were stable in terms of HIV infection, with no history of heart disease
or other chronic systemic disease except HIV infection. Patients were on HAART with good immunological control. Standard
echocardiographic measures of LV-RV function were assessed. Tricuspid annular systolic plane excursion (TAPSE) was
measured by M-mode of the lateral tricuspid valve annulus. LV global longitudinal, circumferential and radial strains were
calculated. Global area strain (GAS) was calculated by 3DSTE as percentage variation in surface area defined by the longitudinal
and circumferential strain vectors. Right ventricular (RV) 3D global and free-wall longitudinal strain was obtained. Data
analysis was performed offline.
Results:
LV global longitudinal strain and GAS were lower in HIV patients compared to normal controls (-15.9% vs -19.1%,
p=0.013, and -33.9% vs -38.7%, p=0.004, respectively). There were no significant differences in ejection fractions between
the groups. There was a trend toward reduced TAPSE in HIV patients compared to controls (20.2±2.3mm vs 23.4±2.6mm,
p=0.08). RV free-wall longitudinal strain was significantly reduced in HIV patients when compared with the control group
(-19.8% vs -23.7%, p=0.025). No patient had pulmonary systolic pressure higher than 35mmHg. There was no correlation
between echocardiographic parameters and selected biomarkers and inflammatory markers.
Conclusions:
Three-dimensional speckle tracking echocardiography may help to identify HIV patients at high cardiovascular
risk allowing early detection of biventricular dysfunction in the absence of pulmonary hypertension.
cardiodiagnostica@gmail.com