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conferenceseries
.com
Volume 12
Journal of Molecular and Genetic Medicine
ISSN: 1747-0862
May 21-23, 2018 Barcelona, Spain
&
Integrative Biology
6
th
International Conference on
Genomics and Molecular Biology
10
th
International Conference on
Genomics 2018 and Integrative Biology 2018
May 21-23, 2018
JOINT EVENT
Association between plasminogen activator inhibitor-1-675 4g/5g insertion/deletion polymorphism
and chronic obstructive pulmonary disease
Rabab El Wahsh
Menoufia University, Egypt
M
olecular pathology of chronic obstructive pulmonary disease (COPD) is still being investigated to discover relationships
with disease pathogenesis. Evidence of plasminogen activator inhibitor-1 (PAI-1) overexpression in the sputum and the
blood of COPD patients is growing. We aimed to investigate the potential relation between PAI-1 promoter 4G/5G insertion/
deletion polymorphism and COPD development. In a case-control study, we genotyped 117 COPD patients and 160 control
subjects for PAI-1 promoter 4G/5G polymorphism by an allele-specific polymerase chain reaction analysis. All subjects were
male smokers. In the co-dominant model, there was a significant difference in the distribution of 5G/5G, 4G/5G and 4G/4G
genotypes between COPDpatients and controls (p=0.002). In the recessivemodel, carriers of 4G/4G genotype were significantly
higher in COPD patients than controls (p=0.01). Carriers of 4G/4G genotype were at higher risk to develop COPD than those
carrying 5G/5G or 4G/5G genotypes (crude odds ratio (OR)=2.10, 95% confidence interval (CI)=1.19-3.73, adjusted OR=2.5,
95% CI=1.22-3.99). PAI-1 4G/5G genetic variations are associated with COPD development in males.
rababwahsh@yahoo.comJ Mol Genet Med 2018, Volume 12
DOI: 10.4172/1747-0862-C2-028