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Volume 5, Issue 3 (Suppl)
Mod Chem Appl, an open access journal
ISSN: 2329-6798
Global Chemistry 2017
September 04-06, 2017
September 04-06, 2017 | London, UK
5
th
Global Chemistry Congress
Preparation of modified thionucleobases and thionucleosides using room temperature ionic liquids as solvents
Qinguo Zheng
and
Xiaomei Hu
Aston University, UK
N
ucleoside chemistry is an important research area in drug development. Various kinds of chemical modified nucleobases,
nucleosides, nucleotides and oligonucleotides have shown biological activities. One of the challenges associated with the
nucleoside chemistry is the poor solubility of these compounds in the commonly used organic solvents. The conventional polar
solvents such as DMF, DMSO and N-methylpyrrolidone (NMP) have been employed, but they are hazardous to the environment.
Thus, there is a need to develop alternative solvents and technologies for nucleoside chemistry due to the increasing need for
protecting the environment. Good solubility of these chemicals in ionic liquids provides an opportunity to solve this problem.
Considering the advantages of using ionic liquids for nucleoside chemistry, as a part of our continuous efforts in utilization of
ionic liquids for various synthetic reactions, we have synthesized modified thionucleobases and thionucleosides using various RTILs
with the aim of developing anti-viral and anti-cancer agents. Ionic liquids 1-methoxyethyl-3-methylimidazolium methanesulfonate
{[MeOEtMIM]
+
[CH
3
SO
3
]
ˉ
} and 1-methoxyethyl-3-methylimidazolium trifluoroacetate {[MeOEtMIM]
+
[CF
3
COO]
ˉ
} have been used
as solvents and catalysts for the preparation of modified thionucleobases and thionucleosides. These reactions proceeded effectively
and efficiently in various ionic liquids.
Biography
Qinguo Zheng is the Professor in School of Life & Health Sciences at Aston University, UK. His research interests are development of novel methodologies for
synthesis of modified nucleic acids and peptide nucleic acids, and their use as potential antisense therapeutic agents. He has completed post doctorate from MRC
Toxicology Unit, University of Leicester, UK.
zheng@aston.ac.ukQinguo Zheng et al., Mod Chem Appl 2017, 5:3(Suppl)
DOI: 10.4172/2329-6798-C1-005