9 / 20
Page 34
Notes:
conferenceseries
.com
Volume 5, Issue 3 (Suppl)
Mod Chem Appl, an open access journal
ISSN: 2329-6798
Global Chemistry 2017
September 04-06, 2017
September 04-06, 2017 | London, UK
5
th
Global Chemistry Congress
Palladium-catalyzed domino Heck/aryne carbopalladation/C-H functionalization: Synthesis of heterocycle-
fused 9, 10-dihydrophenanthrenes
Tuanli Yao
Shaanxi University of Science and Technology, China
A
rynes generated from the corresponding o-(trimethylsilyl) aryl triflates have emerged as powerful synthons in organic synthesis.
Aryne annulation reactions with intramolecular C-H functionalization can be a powerful method for the synthesis of polycyclic
compounds. We developed a novel palladium-catalyzed domino Heck/aryne carbopalladation/C-H functionalization reaction using
in situ
generated arynes, in which three new C-C bonds and a carbon quaternary center are formed. This methodology affords
moderate to excellent yields of heterocycle-fused 9, 10-dihydrophenanthrenes.
Biography
Tuanli Yao has completed his PhD from Iowa State University and Post-doctoral studies from University of California, Berkeley. He worked as Senior Scientist at
Deciphera Pharmaceuticals and Associate Researcher at University of Kansas. Currently, he is a Professor at Shaanxi University of Science & Technology. His
research interests include “Aryne chemistry, electrophilic cyclization and palladium catalysis”. He has published more than 30 papers in reputed journals.
yaotuanli@sust.edu.cnTuanli Yao, Mod Chem Appl 2017, 5:3(Suppl)
DOI: 10.4172/2329-6798-C1-005