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Volume 7, Issue 4 (Suppl)

J Clin Trial

ISSN: 2167-0870 JCTR, an open access journal

Global Pharmacovigilance 2017

July 06-07, 2017

JULY 06-07, 2017 KUALA LUMPUR, MALAYSIA

GLOBAL

Pharmacovigilance &

Drug Safety Summit

Predictive value of end-tidal CO

, lung mechanics and other standard parameters for weaning

neurological patients from mechanical ventilation

Hala A Mohammad and Wegdan A Ali

Minia University, Egypt

Background:

Neurologic related respiratory failure from severe central nervous system dysfunction is one of the most frequent

reasons for initiating mechanical ventilation. The present study aimed to determine the value of EndTidal CO

and lung

mechanics as predictors of extubation failure in different neurological patients who were putting on mechanical ventilation.

Methods:

32 critically ill neurological patients were admitted to the general ICU with acute respiratory failure due to variable

neurological insults including acute stroke, drug abuse, toxins, and C

lesion. The patients were assessed for the following

outcomes measures: Lung mechanics (compliance, airway resistance andMIP), ETCO

, and the other standard weaning success

indices including; PaO

/FiO

, pH, and rapid shallow breathing index (RSBI) (respiratory rate/tidal volume) at subsequent

times: Initially on the beginning of using MV, and finally before extubation.

Results:

Successfully weaned patients represented 56.2% (n=18) of all patients included in this study. They had a significantly

lower MV duration (3.75±1.8 days) and had a significantly higher Glasgow Coma Scale (13.16±1.29) than the failed weaning

group. Logistic regression analysis showed a significant association between failure of weaning and each of age, MV duration,

Glasgow Coma Scale <13(GCS), ETCO

621.1 and MIP≥16.

Conclusion:

We concluded that measurements of RSBI, MIP (maximum inspiratory pressure), EndTidal CO

and dynamic

compliance were more accurate predictors of extubation failure in patients with neurological insults than other standard

weaning parameters.

J Clin Trial 2017, 7:4 (Suppl)

DOI: 10.4172/2167-0870-C1-017