10 / 20
Page 43
conferenceseries
.com
Volume 7, Issue 4 (Suppl)
J Clin Trial
ISSN: 2167-0870 JCTR, an open access journal
Global Pharmacovigilance 2017
July 06-07, 2017
JULY 06-07, 2017 KUALA LUMPUR, MALAYSIA
8
TH
GLOBAL
Pharmacovigilance &
Drug Safety Summit
J Clin Trial 2017, 7:4 (Suppl)
DOI: 10.4172/2167-0870-C1-017
Multifaceted role of gamma-Tocotrienol in cancer therapy
Gautam Sethi
National University of Singapore, Singapore
G
amma-Tocotrienol, a member of Vitamin E super-family has attracted great attention of late for its anti-proliferative and
anti-carcinogenic potential against different cancers. For example, our group has recently reported that anti-proliferative
and chemo-sensitizing effects of Gamma-tocotrienol are associated with its ability to suppress activation of signal transducers
and activator of transcription 3 (STAT3), a pro-inflammatory transcription factor that plays a pivotal role in the survival,
proliferation, angiogenesis and chemo-resistance of hepatocellular carcinoma. However, the potential of gamma-tocotrienol
to overcome chemo-resistance in gastric cancer, which is one of the deadliest cancers in Asia-pacific region, has never been
explored before. Hence, we investigated the efficacy of Gamma-tocotrienol in combination with capecitabine to modulate
tumor growth and survival in xenograft mouse model. Gamma-tocotrienol also inhibited expression of various oncogenic
proteins, induced PARP cleavage and inhibited NF-κB activation in gastric cancer cells.
In vivo
studies using xenograft model
of human gastric cancer demonstrated that gamma-tocotrienol alone suppressed tumor growth and this effect was further
potentiated in conjunction with capecitabine. As compared to the vehicle control, gamma-tocotrienol further suppressed the
NF-κB activation and expression of cyclin D1, COX-2, ICAM-1, MMP-9 and survivin in tumor tissues obtained from treatment
groups. Additionally we noted, that gamma tocotrienol can function as a potent inhibitor of angigogenesis in both HUVEC
and HCC cells. Overall our results suggest for the first time that gamma-tocotrienol can potentiate the effects of chemotherapy
through modulation of multiple biomarkers of proliferation and angiogenesis in diverse cancers.
gautam_sethi@nuhs.edu.sg