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conferenceseries.com
February 20-21, 2017 Berlin, Germany
9th International Congress on
Nutrition & Health
Volume 7 Issue 1 (Suppl) J Nutr Food Sci
ISSN:2155-9600 JNFS, an open access journal Nutrition & Health 2017
February 20-21, 2017 Berlin, Germany
Ketmanee Senaphan et al., J Nutr Food Sci 2017, 7:1 (Suppl)
Ferulic acid ameliorates oxidative stress, endothelial dysfunction and vascular remodeling in high-
carbohydrate and high-fat diet fed rats
Ketmanee Senaphan, Weerapon Sangartit, Upa Kukongviriyapan and Veerapol Kukongviriyapan
Khon Kaen University, Thailand
Statement of Problem: Chronic intake of high-carbohydrate and high-fat (HCHF) diet causes metabolic abnormalities, including
insulin resistance, dyslipidemia and hypertension. Decreased nitric oxide (NO) bioavailability and increased angiotensin II signaling
are implicated in the pathogenesis of endothelial dysfunction and hypertension by accelerating the formation of reactive oxygen
species. Therefore, current nutritional advice emphasizes the benefits of fruit and vegetable consumption. Ferulic acid (FA) is a major
phenolic compound found in rice oil, cereals and various types of fruits and vegetables. This study was designed to test whether FA
supplementation could reduce oxidative stress, endothelial dysfunction and vascular remodeling in rats fed a HCHF diet.
Methodology &Theoretical Orientation: Male Sprague- Dawley rats were fed either a standard chow diet and tap water or a HCHF
diet with 15% fructose solution for 16 weeks. HCHF rats were treated orally with FA (30 and 60 mg/kg/day) for the final 6 weeks of
the experimental period. At the end of the experiment, hemodynamic status, vascular functional and structural changes, oxidative
stress markers, angiotensin-converting enzyme (ACE) activity and angiotensin II type 1 receptor (AT1R) expression were measured.
Findings: FA reduced oxidative stress via suppressing p47 phox NADPH oxidase and increasing eNOS expression. FA decreased
arterial blood pressure, reduced aortic stiffening and improved endothelial dysfunction by increasing the endothelium-dependent
vasodilator responses. Moreover, FA reduced HCHF diet-induced hypertrophic remodeling of the aortic wall and decreased matrix
metalloproteinase-2 (MMP-2) and MMP-9 expression. The ameliorative effects of FA were associated with a reduction of ACE activity
and downregulation of AT1R, indicating that FA could inhibit the renin-angiotensin system.
Conclusion & Significance: Overall findings suggest the beneficial effect of FA on preventing vascular complications in metabolic
syndrome.
Biography
Ketmanee Senaphan has done her DVM from Khon Kaen University, Thailand in the year 2011. She has completed her PhD in Medical Physiology from Khon Kaen
University, Thailand, 2016. She has received a Scholarship i.e., The Royal Golden Jubilee PhD Program, the Thailand Research Fund. Her research interests are
Endothelial dysfunction, arterial stiffening and vascular remodeling in animal models of metabolic syndrome, diabetes and hypertension, with special focus on many
dietary antioxidants in improvement of cardiovascular function and reduction of cardiovascular risk.