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Pain Medicine 2017
October 19-20, 2017
Volume 6, Issue 6 (Suppl)
J Pain Relief, an open access journal
ISSN: 2167-0846
October 19-20, 2017 San Francisco, USA
4
th
International Conference on
Pain Medicine
Multimodal analgesia with pregabalin and dexmedetomidine in morbidly obese patients undergoing
laparoscopic sleeve gastrectomy: A prospective randomized double blind placebo controlled study
Nasr Mahmoud Abdallah
and
Atef Kamel Salama
Cairo University, Egypt
Background & Objectives:
Sleeve gastrectomy has become a popular and effective treatment for morbidly obese patients. The aim
of this prospective randomized study was to assess the efficacy of multimodal analgesia using pregabalin and dexmedetomidine in
morbidly obese patients undergoing laparoscopic sleeve gastrectomy.
Materials &Methods:
After ethical approval, 60 American Society of Anesthesiologists (ASA) physical status II patients were enrolled
in this study and allocated randomly into 2 groups: Group A received 75 mg oral pregabalin 2 h before surgery and dexmedetomidine
infusion 0.4 lg/kg/h and Group B (control group) received placebo capsule 2 h before surgery and saline infusion intraoperatively.
Intraoperative fentanyl consumption, hemodynamics and postoperative opioid consumption, pain scores, level of sedation and any
side effects were evaluated.
Results:
There was a significant decrease in heart rate, mean arterial blood pressure, pain score, intraoperative fentanyl use,
postoperative morphine consumption and nausea verbal rating scale in Group A as compared to Group B. There was a significant
increase in sedation score in Group A as compared to Group B.
Conclusions:
The combination of preoperative oral pregabalin and intraoperative dexmedetomidine infusion decreased intraoperative
fentanyl use and ensured postoperative better pain control and less postoperative opioid consumption.
sief.nasr@yahoo.comJ Pain Relief 2017, 6:6 (Suppl)
DOI: 10.4172/2167-0846-C1-018