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Pain Medicine 2017
October 19-20, 2017
Volume 6, Issue 6 (Suppl)
J Pain Relief, an open access journal
ISSN: 2167-0846
October 19-20, 2017 San Francisco, USA
4
th
International Conference on
Pain Medicine
The preventive effect of date palm (Phoenix dactylifera) seed and fruit hydroalcoholic extracts on
carrageenan-induced inflammation in male rat’s hind paw
Ardeshir Arzi, Siavash Azarbani, Hanieh zarringhalam, Zahra Nazari
and
Mohsen Rezaei
AJUMS University, Iran
Background & Objective:
The side effects of NSAIDS drugs have caused increasing interest of scientists in herbal medicines as
alternative treatment. In this study, the anti-inflammatory effect of seed and fruit of date palm hydroalcolic extracts, due to having
antioxidants, was studied.
Materials & Methods:
In this study, the extracts of date palm seed and fruit were prepared by maceration method in 70% alcohol.
Eighty male rats Wistar, divided into 10 groups of 8 in each, 4 groups received different doses (100, 200, 400 and 600 mg/kg) of seed
extract and 4 other groups different doses (100, 200, 400 and 600 mg/kg) of fruits extract of the palm, and the positive control aspirin
(300 mg/kg) and the negative control group saline (5 ml/kg) via injection intraperitoneally. Half an hour later all animals received 100
µl of 1% carrageenan into the rats’ hind paw subcutaneous. The changes in rats paw edema was measured by plethysmometer every
hour for 5 hours.
Results:
The effect of all of the doses of date palm seed extract on edema were less than aspirin (P<0.05). But there was no significant
difference between the group that received 400 and 600 mg/kg date palm fruit extract when compared with aspirin group. The dose
400 mg/kg of fruit extract showed the most anti-inflammatory effect and it was assigned as the best dose.
Conclusion:
It is likely that with further studies on different model of animals and also on human model the palm fruit extract could
be used for pain treatment.
siavash.farma@gmail.comJ Pain Relief 2017, 6:6 (Suppl)
DOI: 10.4172/2167-0846-C1-018