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conferenceseries
.com
Volume 7
Pharmaceutical Regulatory Affairs: Open Access
ISSN: 2167-7689
Pharma Europe 2018
May 07-09, 2018
May 07-09, 2018 | Frankfurt, Germany
15
th
Annual European Pharma Congress
Hypoglycemic, hypolipidemic andhistological effects of ethylacetate extract of
Combretumplatypterum
leaves in alloxan induced rats
Fagbohun A B, Fred-Jaiyesimi A A, Sagamu, Nigeria Ndimele B E, Oluboba M A, James E S
and
Ibitoye S F
Olabisi Onabanjo University, Nigeria
Statement of the Problem:
Plants with medicinal properties are rich in phytochemical compounds. Some botanical
polysaccharides have important bioactive components responsible for hypoglycemic effect, while some plants are known to
have hypolipidemic activity. The purpose of this study is to determine the hypoglycemic, hypolipidemic and histological effects
of ethylacetate extract of
Combertum platypterum
leaves in alloxan induced rats.
Methodology&TheoreticalOrientation:
Sequential extractionwas carried out on the plant leaves using n-Hexane, ethylacetate
and methanol. These were concentrated to constant weights. Phytochemical screening was carried out on the crude sample of
Combretum platypterum
leaves. Diabetes was induced in the albino rats by the administration of alloxan monohydrate (150
mg/kg i.p.). The ethylacetate extract of
Combretum platypterum
at different doses of body weight were administered orally at
a single dose per day to the diabetic induced rats for a period of 13 days. The effects of the ethylacetate extract of
Combretum
platypterum
leaves and glibenclamide on blood glucose, plasma lipid and blood chemical parameters were measured in the
diabetic rats. Histological effect of the ethylacetate extract of
Combretum platypterum
leaves was also carried on the liver,
spleen, kidney and heart of the diabetic rats.
Findings:
Phytochemical screening showed the presence of flavonoids, saponins, cardiac glycosides, cyanogenetic glycosides,
tannins and alkaloids, while anthraquinones were absent. Hypoglycemic effect of the ethylacetate extract of
C. platypterum
showed a significant positive effect. Administration of glibenclamide and the ethylacetate extract of
C. platypterum
showed
significant hypolipidemic effect when compared with the reference range. This also caused reduction in total triglyceride and
total cholesterol levels. Histological result showed that
C. platypterum
has no toxic effect on the organs.
Conclusion&Significance:
The ethylacetate extract of
C. platypterum
showed both hypoglycemic and hypolipidemic activities.
Combretum platypterum
has a great potential with activities to lead to desired drug design.
ayodelefagbohun@yahoo.comPharmaceut Reg Affairs 2018, Volume 7
DOI: 10.4172/2167-7689-C1-031