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conferenceseries
.com
Volume 7, Issue 4 (Suppl)
Clin Exp Pharmacol
ISSN: 2161-1459 CPECR, an open access journal
Pharmacology Congress 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
8
th
World Congress on
Pharmacology and Toxicology
The reproductive toxicity of ZishenYutai pill on rats and offspring in perinatal period
Li Zhou, Juan Jiang, Yang Yang, Da-wei Yan, Li Xu, Li-ming Chong
and
Zu-Yue Sun
Shanghai Institute of Planned Parenthood Research Hospital, China
Objective:
ZishenYutai Pill (ZYP) is one of the most commonly used Chinese medicines in prevention of early pregnancy loss
due to threatened and recurrent miscarriage. Although it is widely used, its toxicity during perinatal period has not been well
understood. Its main components include Radix Codonopsis, Radix Dipsaci, Polygoni multiflori,
Atractylodes macrocephala,
Morinda officinalis, Eucommia ulmoides
, Semen cuscutae and Radix rehmanniae praeparata. In recent years, the research on
ZYP has been increased year by year. Previous studies have shown that ZYP combined with phloroglucinol is significantly
effective in the treatment of threatened abortion.
Methods:
Pregnant rats (F
0
) were exposed to 6 g/kg, 12 g/kg and 24 g/kg body weight/d of ZYP by intragastric administration
from gestation day 15 (GD
15
) to through parturition and lactation up to weaning i.e., post-natal day 21 (PND
21
). Water and
propylthiouracil (PTU, 15 mg/kg) were used as the negative control and positive control respectively. The mating was done
between the treatment (ZYP or PTU) group and negative control group when the F1 pups were born on 63 days.
Results:
The reproductive capacity of F
0
and F
1
generation decreased significantly after PTU exposure (P<0.05), however the
body weight and reproductive ability of F
0
, the physical development and feed consumption of F
1
as well as the reproductive
ability and survival rate of F
2
rats were not significantly changed in the ZYP group compared with the negative control group
(P>0.05).
Conclusion:
There was no statistically significant evidence of perinatal toxicity under ZYP exposure.
Biography
Li Zhou has completed her PhD from Beijing Institute of Pharmacology and Toxicology and Postdoctoral studies from Chinese Academy of Medical Sciences.
She is the Deputy Director of National Evaluation Centre for the Toxicology of Fertility Regulating Drug. She has published more than 40 papers in China and
abroad reputed journals.
zhoulijss@163.comLi Zhou et al., Clin Exp Pharmacol 2017, 7:4 (Suppl)
DOI: 10.4172/2161-1459-C1-020