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.com
Volume 8
Journal of Clinical Trials
Pharmacy and Pharmacovigilance 2018
July 16-17, 2018
July 16-17, 2018 Sydney, Australia
Joint Event on
Global Pharmacovigilance and
Advanced Pharmacy
Orodispersible films of a polymorphic poorly soluble drug: Effect of casting solvent, film forming
agent and solubilizer
Ibrahim Al Sharabi and Ahmed Abd El-Bary
Cairo University, Egypt
I
n the current work, a full factorial experimental designwas utilized to formulate piroxicam into orodispersible films while investigating
the effects of some formulation factors on the properties of the resulting films. These factors were: (1) The casting solvent: Water
and acetone/water mixture, (2) the film forming agent: HPMC K4M and Na-alginate and (3) the solubilization system: No solubilizer,
L-arginine, poloxamer and L-arginine/poloxamer mixture. 16 formulation runs were prepared by solvent casting method to obtain
10 mg piroxicam dosage units. Drug particle size in the prepared formulations and dissolution efficiency at 30 minutes were selected
as responses variables. Additionally, the prepared films from each formulation were evaluated for other characters as drug content,
thickness, residual water, etc. A selected formulation was then evaluated for its
in vivo
disintegration, palatability and stability. Utilizing
acetone in the casting solution, Na-alginate as film forming agent or both of them resulted in formation films with larger drug particles
and slower dissolution. Combined use of L-arginine and poloxamer showed better drug dissolution than using each alone. HPMC was
more favorable thanNa-alginate regardingmechanical properties andmoisture absorption. Films from the selected formulation showed
fast
in vivo
disintegration and acceptable palatability. These films were stable for six months under accelerated storage conditions.
ibrahimshar3abi@gmail.comJ Clin Trials 2018, Volume 8
DOI: 10.4172/2167-0870-C2-026