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conferenceseries
.com
Volume 9
Chemical Sciences Journal
Asia Chemistry 2018
September 12-13, 2018
11
th
Annual Congress on
September 12-13, 2018 Singapore
Chemistry
Transition Metal complexes/Organometallic compounds as Anticancer/anti HIV drugs in
Pharmaceutical Industry
Prakash Kinthada
Sri Vidyanikethan Engineering College, India
C
ancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health.
Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and
alternative medicine hoping for a better cure. Research on platinum based drugs and non-platinum based drugs is a multi-million
dollar industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a
long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid,
belonging to a group of Flavonol, Curcumin is a natural Polyphenol. It is highly potential molecule capable of preventing and
treating various cancers. Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic
preparations in Indian System of medicine. The use of these analogs for prevention of cancer tumor progression and treatments
of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions and
particularly breast, prostate and pancreatic cancer in humans and animals. The novel pharmacologic agent is an isoflavonoid or
isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal
salt to formamore potent metal complex, particularly a Au (III) complex and other complexes of platinum, palladium, ruthenium,
copper, etc. My talk would mainly encompass different transition metal complexes/organometallic compounds that are presently
used as drugs, especially anticancer and anti-HIV drugs, apart from anti-inflammatory, antimicrobial, antibacterial and diseases
like arthritis and Parkinson’s disease, etc. The talk would mainly focus on the use of medicinal chemistry and its application to
drug design and development in pharmaceutical industry, especially transition metal complexes and organometallic compounds
viz. gold, platinum, palladium and ruthenium apart from copper, cobalt, iron, nickel, zinc, cadmium, etc. The main emphasis of
my talk would be on different class of ligands, their Schiff ’s bases and transition metal complexes especially Au, Pt, Pd and Ru,
with the main aim of designing, developing very novel small molecules, as possible and extremely potential candidates as anti-
cancer and anti-HIV drugs. We have synthesized and characterized several phytochemicals from traditional medicinal plants and
isolated some phytochemicals and made the corresponding Oximes, Thiosemicarbazones and substituted Thiosemicarbazones
as ligands and synthesized, characterized, structurally elucidated their transition metal complexes especially with gold, platinum,
palladium, ruthenium, copper, etc. and studied their anticancer activity, nuclease activity and tested their potential as anticancer
drugs. The main aim of our extensive/preclinical pharmaceutical development program is to investigate the use of these extremely
novel small molecules-metal complexes/compounds of Phytochemicals, Flavonoids, etc., which have very interesting structural
features and properties and hence are excellent candidates as Anti-cancer and Anti-HIV drugs.
pk6030882@gmail.comChem Sci J 2018, Volume 9
DOI: 10.4172/2150-3494-C5-030