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conferenceseries
.com
Volume 9
Chemical Sciences Journal
Asia Chemistry 2018
September 12-13, 2018
11
th
Annual Congress on
September 12-13, 2018 Singapore
Chemistry
Chem Sci J 2018, Volume 9
DOI: 10.4172/2150-3494-C5-030
Development of a novel and efficient route to the Tropomyosin-Related Kinase (Trk) inhibitor
Larotrectinib (LOXO-101)
Yong Zhang
Southeast University, China
L
arotrectinib (LOXO-101) is a small-molecule ATP-competitive oral inhibitor of the Tropomyosin-Related Kinase (Trk)
family of receptor kinases, including Trk-A, Trk-B and Trk-C kinases. Herein, a novel and efficient route for the synthesis of
Larotrectinib using starting materials that are commercially available has been achieved. The procedure employed mild reaction
conditions and avoided the use of expensive reagents compared to the original synthetic route reported by Array BioPharma.
More importantly, gram scale synthesis was accomplished and this protocol could be valid in the synthesis of similar drugs.
zy_zhiyao@126.com