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Chromatography 2016
September 21-23, 2016
Volume 7, Issue 5(Suppl) J Chromatogr Sep Tech 2016
ISSN: 2157-7064 JCGST, an open access journal
conferenceseries .com
September 21-23, 2016 Amsterdam, Netherlands
World Congress on Chromatography
Implementation of UHPLC-single quad MS platform: The next level transforming pharmaceutical
quality control laboratories
Evelien Wynendaele, Gevaert Bert, Veryser Lieselotte, Xu Xiaolong, Verbeke Frederick and De Spiegeleer Bart
Ghent University, Belgium
In pharmaceutical analysis, the use of mass spectrometry (MS) coupled to liquid chromatography in quality control has
become very significant. This is observed in i. a. the European Pharmacopoeia, where this technique is already incorporated
in different general texts as well as specific monographs. Here, often (GMP) single quadMS platforms can be used, characterized
by acceptable low costs, easy-to-use smooth lab-integration, increased efficiency and providing additional detection possibilities
over a traditional UV/VIS detector. Single quad mass spectrometers also work well as analytical tools for the detection of low-
abundant genotoxic impurities and their basic confirmation. Moreover, also in drug development, this detector can be useful:
low UV-detectable impurities, obtained during synthesis, formulation or after degradation, can be analyzed, even in complex
matrices. In developmental quality control of complex mixtures (e.g. plant extracts), the UPLC-single quad MS platform was
found to be of great use in transdermal research as well.
Biography
Evelien Wynendaele has completed her PhD in Pharmaceutical Sciences in 2014 at Ghent University. She is currently working as a Post-doctoral fellow in the
DruQuaR Laboratory at the same university, under the supervision of Prof. Bart De Spiegeleer. She has published more than 35 papers in reputed journals.
Evelien Wynendaele et al., J Chromatogr Sep Tech 2016, 7:5(Suppl)