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Chromatography 2016
September 21-23, 2016
Volume 7, Issue 5(Suppl) J Chromatogr Sep Tech 2016
ISSN: 2157-7064 JCGST, an open access journal
conferenceseries .com
September 21-23, 2016 Amsterdam, Netherlands
World Congress on Chromatography
Elution order switchable chiral stationary phases for HPLC based on switching and memory of helicity
in polyacetylenes in the solid state
Katsuhiro Maeda
Kanazawa University, Japan
S eparation of enantiomers by high-performance liquid chromatography (HPLC) is an effective method both for analyzing
enantiomer composition of chiral compounds and obtaining pure enantiomers. Although a large number of chiral stationary
phases (CSPs) for HPLC have been developed, it is still a challenging issue to switch the elution order of enantiomers under
identical chromatographic conditions. Recently, we have found that a polyacetylene derivative bearing 2,2’-biphenol-derived
pendants can form a preferable helical conformation in response to the chirality of non-racemic guest compounds, such as
1-phenylethanol (PEA), in the solid state as well as in solution, and the induced preferred-handed macromolecular helicity can
be maintained, that is memorized, even after complete removal of the chiral guests. By taking advantage of this unique feature,
we have succeeded in developing an unprecedented switchable CSP for HPLC, in which the elution order of the enantiomers
can be switched, which will be based on reversible switching and subsequent memory of the macromolecular helicity by the
treatment with (R)- and (S)-PEA in the solid state. In order to improve the chiral recognition ability, we synthesized analogous
polyacetylene derivatives with ester or carbamate groups as the effective interaction sites and investigated a relationship
between the structures of the pendants and the recognition abilities of the polymers. Repetitive switching of the elution order
of enantiomers based on the switching of the macromolecular helicity was achieved by immobilizing these polymers onto silica
support.
Biography
Katsuhiro Maeda has received his BS (1993), MS (1995) and PhD (1998) degrees from Nagoya University. In 1998, he joined the Graduate School of Molecular
Design and Engineering, Nagoya University, as an Assistant Professor and was promoted to an Associate Professor in 2002. He moved to Kanazawa University in
2008 and was appointed as a Full Professor in 2015. He has published more than 80 original papers in various reputed journals.
Katsuhiro Maeda, J Chromatogr Sep Tech 2016, 7:5(Suppl)