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conferenceseries
.com
Volume 6
Journal of Neurological Disorders
ISSN: 2329-6895
CNS 2018
November 12-13, 2018
November 12-13, 2018 | Edinburgh, Scotland
4
th
International Conference on
Central Nervous System Disorders & Therapeutics
Association of the presence of neurospheres with treatment response and survival rate of children
with astrocytoma
López-Aguilar E
Brain Tumor Research Laboratory, Pediatric Hospital "Dr. Silvestre Frenk Freund", Mexican Institute of Social Security, Mexico
Background and Aim:
Astrocytomas are the most common primary central nervous system (CNS) tumors in children being
the leading cause of solid cancer related death in childhood. Neurospheres formation and the ability of tumor cells to proliferate
in culture along with key factors such as age, location, histology and Ki67, p53, EGFR markers are deemed as powerful tools
to predict the clinical outcome of patients with astrocytomas. In this study we associate the survival rate and the response to
treatment according to the formation of self-renewable neurospheres in consecutive passages of cell cultures of patients with
astrocytomas.
Results:
Our results showed a current survival rate of 18 patients (75%) and 6 deaths with an overall survival rate at 24
months. Patients who had neurospheres in basal culture have 39.51% survival rate at 24 months compared to those without
neurospheres in basal culture medium with 81.48% survival rate at 24 months. Of the six patients who have died, four had
neurospheres both in the basal culture medium and in the first passage. Regarding treatment response at six months, four out
of five patients with progressive disease had neurospheres both in the basal culture medium and in the first passage, three of
these patients had neurospheres in the second passage and two in the third passage. Instead of seven patients with complete
response at six months, only one patient had neurospheres both in the basal culture medium and in the first passage.
Conclusion:
We found a clear association between the development of neurospheres and the evolution of our patients.
onco_lab@yahoo.com.mxJ Neurol Disord 2018, Volume 6
DOI: 10.4172/2329-6895-C9-050