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Dementia 2016
September 29-October 01, 2016
Volume 6 Issue 5(Suppl)
J Alzheimers Dis Parkinsonism 2016
ISSN:2161-0460 JADP, an open access journal
conferenceseries
.com
September 29-October 01, 2016 London, UK
5
th
International Conference on
Alzheimer’s Disease & Dementia
Sang Moo Lim, J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)
http://dx.doi.org/10.4172/2161-0460.C1.022Clinical Usefulness of [
18
F]FC119S PET as an Auxiliary Diagnostic Methods for Dementia
Sang Moo Lim
Korea Institute of Radiological and Medical Sciences (KIRAMS), Republic of Korea
T
he newly developed
18
F-labeled amyloid tracer, 2-[2-(N-monomethyl)aminopyridine-6-yl]-6-[(S)-3-[
18
F]fluoro-2-
hydroxypropoxy]benzothiazole ([
18
F]FC119S) was recently introduced. We assessed the usefulness of [
18
F]FC119S PET
as an auxiliary diagnostic methods for dementia. 1) For the comparison of [11C]PiB PET and [
18
F]FC119S PET, a total of 48
subjects-clinically diagnosed Alzheimer’s disease (AD) in 10, mild cognitive impairment (MCI) in 10, and congnitive normal
subjects (CN) in 28-underwent both [
11
C]PiB PET and [
18
F]FC119S PET. 2) To assess the diagnostic performance of [
18
F]
FC119S, a total of 100 subjects-AD in 50, non-Alzheimer’s dementia (NAD) in 15, and CN in 35-underwent brain [
18
F]FC119S
PET. 1) The concordance rate of visual analysis of [
11
C]PiB PET and [
18
F]FC119S PET was 98% (44 of 45 cases) and the SUVR
of [
11
C]PiB PET and [
18
F]FC119S PET significantly correlated (r = 0.844, p < 0.001). 2) Based on visual analysis, 45 of 50 cases
with AD (90%), 6 of 15 cases (40%) with NAD (40%), and 1 of 35 CN cases (3%) were read as positive scans, respectively.
Therefore, visual assessment of [
18
F]FC119S PET yielded a sensitivity of 90% and a specificity of 86%. The mean values of SUVR
were 1.22±0.16 in AD, 1.05±0.06 in NAD, and 1.02±0.06 in CN subjects, respectively. SUVR yielded a sensitivity of 84% and
specificity of 84% at the criterion of SUVR > 1.07. There were no clinically significant adverse effects during trial periods. [
18
F]
FC119S PET yields high sensitivity and specificity for identifying AD and therefore may be an auxiliary diagnostic methods
for dementia, especially to exclude AD.
Biography
Sang Moo Lim is the director of the department of nuclear medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of Korea.
nmbbh@hanmail.net