dementia-2016_posters-accepted-abstracts

15 / 26

Notes:
Page 87
Dementia 2016
September 29-October 01, 2016
Volume 6 Issue 5(Suppl) J Alzheimers Dis Parkinsonism 2016
ISSN:2161-0460 JADP, an open access journal
conferenceseries .com
September 29-October 01, 2016 London, UK
5th International Conference on
Alzheimer’s Disease & Dementia
Gun Young Jung, J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)
XHC restores cognition ofAlzheimer’s disease mice and reduces amyloid beta burden via repressing
BACE1 promoter activity
Gun Young Jung
Sungkyunkwan University School of Pharmacy, Republic of Korea
Alzheimer’s disease (AD) is a chronic neurodegenerative disease. In developed countries, AD is one of the most financially
costly diseases however, the cause of AD is still unclear. Among the many hypotheses, Amyloid hypothesis postulated
that exceed extracellular amyloid beta (Aβ) deposits are the fundamental cause of the disease. Aβ is produced by sequential
proteolysis to amyloid beta precursor protein (APP) by β-secretase (BACE1) and γ-secretase. Another important phenomenon
in AD patient is increased BACE1 expression. Many big pharmaceutical companies have been focused on developing direct
inhibitors for BACE1. However, direct and complete blocking of enzymatic activity of BACE1 can cause unpredictable side
effects because of numerous physiological substrates of BACE1. Therefore, our strategy is to find specific drugs reducing BACE1
expression rather than direct inhibition of BACE1. Using USA FDA approved drug library (Prestwick Chemical Library), we
could discover putative therapeutic chemicals by cell based assay. Among those candidates, XHC reduced the levels of BACE1
protein and mRNA in SH-SY5Y cells. A soluble APPβ and C99 which are the products of BACE1 protease, were also decreased
by treatment of XHC. We also confirmed that XHC could improve cognitive functions of 3xTg-AD mice. Decreased level of
Aβ deposition and BACE1 expression also observed in XHC-treated AD mice.
Biography
Gun Young has completed his B.S. from Sungkyunkwan University School of Pharmacy in 2015. He is doing his master’s degree at Sungkyunkwan University
School of Pharmacy. His major expertise is molecular cell biology.